NIH HPC News & Announcements
Biowulf 20th anniversary seminar series: Ryan Dale (NICHD)
Date: 27 March 2019 14:03:28
From: Susan Chacko
The Biowulf 20th Anniversary Seminar Series continues with:
Integrative analyses of gene regulation via long-range chromatin
interactions
Ryan Dale
Scientific Information Officer and Bioinformatics Core Lead, NICHD
Tuesday, 9 April 2019
11 am - noon
Bldg 50, Rm 1227
This talk will be videocast at
https://videocast.nih.gov/summary.asp?live=31795
Abstract:
Throughout development, gene expression is regulated in part by
interactions between gene promoters and distal enhancers that can be
tens or hundreds of kilobases away. Our recent work has identified novel
mechanisms of such long-range regulation in fly and mouse models. In
Drosophila, Argonaute2 is canonically part of the post-transcriptional
siRNA silencing machinery. We show it also plays a role in transcription
regulation via chromatin topology and RNA PolII phosphorylation though
integrative analysis of RNA-seq, ChIP-seq, ChRIP-seq, and 4C-seq assays.
In mouse, the erythroid transcription factor LDB1 is known to
homodimerize to facilitate enhancer-promoter interactions, but by
combining new data with published work we show that it can also interact
with the architectural protein CTCF to promote the erythroid gene
program in mouse. The software infrastructure that makes such
integrative analyses possible -- and reproducible -- will also be
highlighted.
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