Biowulf High Performance Computing at the NIH

Covid-19 Research Support on Biowulf

Covid-Related Projects

21.2+ Million CPU hours used
493+ Thousand jobs run

3D structural model
of the coronavirus spike protein
[Mario Borgnia, NIEHS]
Coronavirus-related work being performed on Biowulf by NIH intramural researchers includes:

Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

Peer-Reviewed Scientific Papers Utilizing Biowulf

thumbnail image from paper GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
Hattori, SI; Higshi-Kuwata, N; Raghavaiah, J et al.
mBio (2020)

thumbnail image from paper In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression
Sinha, S; Cheng, K; Schäffer, AA; Aldape, K; Schiff, E; Ruppin, E;
Mol. Syst. Biol. (2020)

thumbnail image from paper Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Riva, L; Yuan, S; Yin, X et al.
Nature (2020)

Covid-Related Preprint Papers Utilizing Biowulf

Preprints are complete and public drafts of scientific documents, not yet peer reviewed. (More about preprints)

thumbnail image from paper Using multiple data streams to estimate and forecast SARS-CoV-2 transmission dynamics, with application to the virus spread in Orange County, California
Fintzi, J; Bayer, D; Goldstein, I et al.
ArXiv (2020)

thumbnail image from paper Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15
Pillon, MC; Frazier, MN; Dillard, LB et al.
bioRxiv (2020)

thumbnail image from paper Genomic Diversity of SARS-CoV-2 During Early Introduction into the United States National Capital Region
Theilen PM; Wohl S; Mehoke T; et al
medRxiv (202)

thumbnail image from paper An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19
McGregor, R; Chauss, D; Freiwald, T et al.
bioRxiv (2020)

thumbnail image from paper SARS-CoV2 drives JAK1/2-dependent local and systemic complement hyper-activation
Yan, B; Freiwald, T; et al
researchsquare (2020)

thumbnail image from paper Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
Onabajo, OO; Banday AR; et al
bioRxiv (2020)

thumbnail image from paper An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19
McGregor R; Chauss, D; et al.
bioRxiv (2020)

thumbnail image from paper Societal heterogeneity contributes to complex dynamic patterns of the COVID-19 pandemics: insights from a novel Stochastic Heterogeneous Epidemic Model (SHEM)
Maltsev, AV; Stern, M;
medRxiv (2020)

thumbnail image from paper Statistical Physics of Epidemic on Network Predictions for SARS-CoV-2 Parameters
Han, J; Cresswell-Clay, EC; Periwal, V
ArXiv (2020)

thumbnail image from paper Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular Simulations
Ghorbani, M; Brooks, BR; Klauda JB
bioRxiv (2020)

thumbnail image from paper Systematic Cell Line-Based Identification of Drugs Modifying ACE2 Expression
Sinha, S; Cheng, K; Aldape, K; Schiff, E; Ruppin, E
preprints.org (2020)

thumbnail image from paper COVID-19-CT-CXR: a freely accessible and weakly labeled chest X-ray and CT image collection on COVID-19 from biomedical literature
Peng, Y; Tang, YX; Lee, S; Zhu, Y; Summers, RM; Lu, Z;
ArXiv (2020)thumbnail image from paper Global prediction of unreported SARS-CoV2 infection from observed COVID-19 cases
Chow, CC; Chang, JC; Gerkin, RC; Vattikuti, S;
medRxiv (2020)

thumbnail image from paper Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
Hennighausen, L; Lee, HK;
bioRxiv (2020)

thumbnail image from paper Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
Singh, K; Chen, YC; Judy, JT; Seifuddin, F; Tunc, I; Pirooznia, M;
bioRxiv (2020)