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Covid-Related Projects
21.2+ Million CPU hours used
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| 3D structural model of the coronavirus spike protein [Mario Borgnia, NIEHS] |
- Covid-19 transmission modeling [Dean Follman group, NIAID]
- Assessing newly generated and previously known compounds for activity against SARS-Cov-2 [Hiroaki Mitsuya group, NCI]
- Investigation of pathogenic characteristics of COVID-19 by analysis of RNA-seq data from human patients [Lothar Hennighausen group, NIDDK]
- Deep Learning models of chest Xray and CT images [Ronald Summers group, CC]
- Investigating the transcriptional regulators of hyper-inflammatory responses to SARs-CoV2 infection [Behdad Afzali group, NIDDK]
- Identification of drugs that can be repurposed for COVID-19 [Eytan Ruppin group, NCI]
- MD simulation of SARS-CoV-2 spike protein [Peter Kwong group, NIAID_VRC]
- Cryo-electron microscopy of virus proteins and complexes [Natalia de Val & Eric Freed group, NCI_CCR]
- Transcriptomics and network analysis of SARS-CoV-2 infection [Mehdi Pirooznia & Robert Balaban group, NHLBI]
- Simulations of infection spread in populations [Vipul Periwal group, NIDDK]
- Genetic Determinants of Susceptibility to Severe COVID-19 Infection [NIAID Consortium. Director: Helen Su group, NIAID]
- MD Simulations and Glycan Network Analysis of SARS-COV-2 spike protein [Bernard Brooks group, NHLBI]
- Atomic-level structure of the SARS-CoV-2 spike using cryo-electron microscopy [Peter Kwong group, NIAID_VRC]
- Genome-wide association study of COVID-19 genetic variants vs. phenotypes in the UK BioBank [Andrew Johnson group, NHLBI]
- SARS-CoV-2 RNA structural analyses [Markus Hafner group, NIAMS]
- Metagenomics of Covid-19 family [Xiaofang Jiang group, NLM]
- Modeling unreported SARS-Cov2 infection from observed cases [Carson Chow group, NIDDK]
- Studying Interferon-induced variability in ACE2 expression levels [Liudmila Prokunina-Olsson group, NCI]
- In silico screening of drug candidates [Nadya Tarasova & Giorgio Trinchieri group, NCI]
- Stochastic modeling of COVID-19 pandemic infection patterns [Michael Stern group, NIA]
- Structure of complexes of the SARS-CoV-2 ectodomain with a variety of ligands [Mario Borgnia & William Copeland group, NIEHS]
- Text mining of COVID-related scientific literature in LitCovid and CORD-19 [Zhiyong Lu group, NLM/NCBI]
- Modeling, global surveillance, real-time genomic sequencing and phylodynamics of SARS-CoV-2 [Cecile Viboud group, FIC]
- Image processing and text mining of clinical data for the NIAID COVID Data Management Working Group [Robert Hohman group, NIAID]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.
GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
Hattori, SI; Higshi-Kuwata, N; Raghavaiah, J et al.
mBio (2020)
In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression
Sinha, S; Cheng, K; Schäffer, AA; Aldape, K; Schiff, E; Ruppin, E;
Mol. Syst. Biol. (2020)
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Riva, L; Yuan, S; Yin, X et al.
Nature (2020)
Preprints are complete and public drafts of scientific documents, not yet peer reviewed. (More about preprints)
Using multiple data streams to estimate and forecast SARS-CoV-2 transmission dynamics, with application to the virus spread in Orange County, California
Fintzi, J; Bayer, D; Goldstein, I et al.
ArXiv (2020)
Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15
Pillon, MC; Frazier, MN; Dillard, LB et al.
bioRxiv (2020)
Genomic Diversity of SARS-CoV-2 During Early Introduction into the United States National Capital Region
Theilen PM; Wohl S; Mehoke T; et al
medRxiv (202)
An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19
McGregor, R; Chauss, D; Freiwald, T et al.
bioRxiv (2020)
SARS-CoV2 drives JAK1/2-dependent local and systemic complement hyper-activation
Yan, B; Freiwald, T; et al
researchsquare (2020)
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
Onabajo, OO; Banday AR; et al
bioRxiv (2020)
An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19
McGregor R; Chauss, D; et al.
bioRxiv (2020)
Societal heterogeneity contributes to complex dynamic patterns of the COVID-19 pandemics: insights from a novel Stochastic Heterogeneous Epidemic Model (SHEM)
Maltsev, AV; Stern, M;
medRxiv (2020)
Statistical Physics of Epidemic on Network Predictions for SARS-CoV-2 Parameters
Han, J; Cresswell-Clay, EC; Periwal, V
ArXiv (2020)
Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular Simulations
Ghorbani, M; Brooks, BR; Klauda JB
bioRxiv (2020)
Systematic Cell Line-Based Identification of Drugs Modifying ACE2 Expression
Sinha, S; Cheng, K; Aldape, K; Schiff, E; Ruppin, E
preprints.org (2020)
COVID-19-CT-CXR: a freely accessible and weakly labeled chest X-ray and CT image collection on COVID-19 from biomedical literature
Peng, Y; Tang, YX; Lee, S; Zhu, Y; Summers, RM; Lu, Z;
ArXiv (2020)
Global prediction of unreported SARS-CoV2 infection from observed COVID-19 cases
Chow, CC; Chang, JC; Gerkin, RC; Vattikuti, S;
medRxiv (2020)
Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
Hennighausen, L; Lee, HK;
bioRxiv (2020)
Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
Singh, K; Chen, YC; Judy, JT; Seifuddin, F; Tunc, I; Pirooznia, M;
bioRxiv (2020)