The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Sunday, April 14th, 2024
utilization graph
Last 24 hrs
63,286 jobs submitted
51,624 jobs completed
3,107,645 CPU hrs used
20 NIH Institutes
181 Principal Investigators
315 users

Recent Papers that used Biowulf & HPC Resources

Disruption of Ca2+/calmodulin:KSR1 interaction lowers ERK activation
Thines, L; Jang, H; Li, Z et al.
Protein Sci , DOI://10.1002/pro.4982 (2024)

thumbnail image from paper MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
Liu, Z; Zhang, X; Xu, M et al.
PLoS Biol , DOI://10.1371/journal.pbio.3002240 (2024)

thumbnail image from paper Electric Field Characteristics of Rotating Permanent Magnet Stimulation
Robins, PL; Makaroff, SN; Dib, M et al.
Bioengineering (Basel) , DOI://10.3390/bioengineering11030258 (2024)

thumbnail image from paper Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors
Salomon, K; Abramyan, AM; Plenge, P et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2304089120 (2023)

thumbnail image from paper Conserved Noncoding Elements Evolve Around the Same Genes Throughout Metazoan Evolution
Gonzalez, P; Hauck, QC; Baxevanis, AD; ,
Genome Biol Evol , DOI://10.1093/gbe/evae052 (2024)

Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs
He, Y; Pavanello, C; Hutchins, PM et al.
Circulation , DOI://10.1161/CIRCULATIONAHA.123.065959 (2024)

A new method for multiancestry polygenic prediction improves performance across diverse populations
Zhang, H; Zhan, J; Jin, J et al.
Nat Genet , DOI://10.1038/s41588-023-01501-z (2023)

Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
Zong, D; Koussa, NC; Cornwell, JA et al.
Genes Dev , DOI://10.1101/gad.351085.123 (2023)