The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, October 13th, 2026
utilization graph
Last 24 hrs
263,377 jobs submitted
232,978 jobs completed
1,974,906 CPU hrs used
23 NIH Institutes
332 Principal Investigators
714 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 7057 papers)

The relationships between figure rating scale, anthropometric measures, and cardiometabolic outcomes: the AADM study
Doumatey, AP; Idris, A; Zhou, J et al.
Diabetes Metab Syndr , DOI://10.1016/j.dsx.2026.103456 (2026)


A Case of a Fumarate Hydratase Deficient Astrocytoma in Association With a Germline Fumarate Hydratase Mutation With Review of the Literature: Considerations for Patients With Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome
Alfattal, R; Nagarajan, P; O'Brien, B et al.
Am J Surg Pathol , DOI://10.1097/PAS.0000000000002463 (2026)


Quantitative validation of the \"coastline\" heuristic for café-au-lait macule borders in neurofibromatosis type 1 and McCune-Albright syndrome
DiFrischia, M; Hu, P; Waikel, RL et al.
J Am Acad Dermatol , DOI://10.1016/j.jaad.2026.08.007 (2026)


A Novel Sulfatide Analog Recognized by Human iNKT Cells Enhances Polyfunctional Antigen-Specific CD8+ T Cell Responses
Hara, A; DiSapio, J; Coombs, M et al.
Eur J Immunol , DOI://10.1002/eji.70285 (2026)


Secreted filarial acetylcholine analogs modulate parasite reproduction and host physiology
Grote, A; Ficaro, L; Koussa, J et al.
Nat Commun , DOI://10.1038/s41467-026-77090-2 (2026)


Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations
Lee, S; Miller, CL; Bentley, AR et al.
HGG Adv , DOI://10.1016/j.xhgg.2026.100566 (2026)


A new AI assisted approach aligns data standards and accelerates interoperability in biomedical research
Long, RA; Ballard, S; Shah, S et al.
NPJ Digit Med , DOI://10.1038/s41746-026-02795-z (2026)


Cytotoxic Microspinosamides from the Marine Sponge Geodia microspinosa That Decrease Diffuse Pleural Mesothelioma Viability
Orfanoudaki, M; Wang, D; Du, L et al.
Mar Drugs , DOI://10.3390/md24090308 (2026)