Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

88.0+ Million CPU hours used
2.1+ Million jobs run
63 Peer-Reviewed papers
27 Preprint papers

Sample projects (All projects):

  • Surveillance sequencing of SARS-CoV-2 and tracking of emerging variants of concern, Microbiome analysis of respiratory samples from covid19 patients. [NIAID]
  • Atomic-level structure of the SARS-CoV-2 spike using cryo-electron microscopy [NIAID_VRC]
  • Investigating the transcriptional regulators of hyper-inflammatory responses to SARs-CoV2 infection [NIDDK]
  • Cryo-electron microscopy of virus proteins and complexes [NCI_CCR]
  • Text mining of COVID-related scientific literature in LitCovid and CORD-19 [NLM/NCBI]
  • SARS-CoV-2 RNA structural analyses [NIAMS]
  • Covid-19 transmission modeling and crossover trials. Developing models for flow cytometry data that will be used to gain insights into cellular immune responses to COVID-19 [NIAID]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Sunday, November 27th, 2022
utilization graph
Last 24 hrs
50,808 jobs submitted
31,052 jobs completed
2,506,477 CPU hrs used
20 NIH Institutes
152 Principal Investigators
236 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
Hoyt, F; Alam, P; Artikis, E et al.
PLoS Pathog , DOI://10.1371/journal.ppat.1010947 (2022)

thumbnail image from paper Characterization of Oncology Clinical Trials Using Germline Genetic Data
Kammula, AV; Schäffer, AA; Rajagopal, PS; ,
JAMA Netw Open , DOI://10.1001/jamanetworkopen.2022.42370 (2022)

thumbnail image from paper Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors
Chiang, AD; Patil, PP; Beka, L et al.
PLoS Biol , DOI://10.1371/journal.pbio.3001878 (2022)

thumbnail image from paper Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Sudre, G; Gildea, DE; Shastri, GG et al.
Mol Psychiatry , DOI://10.1038/s41380-022-01844-9 (2022)

thumbnail image from paper Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome
Qu, JH; Tarasov, KV; Chakir, K et al.
Cells , DOI://10.3390/cells11213496 (2022)

thumbnail image from paper The Solvation of the E. coli CheY Phosphorylation Site Mapped by XFMS
Hamid, M; Khalid, MF; Chaudhary, SU; Khan, S; ,
Int J Mol Sci , DOI://10.3390/ijms232112771 (2022)

thumbnail image from paper A Bietti Crystalline Dystrophy Mouse Model Shows Increased Sensitivity to Light-Induced Injury
Ma, Z; Jiao, X; Agbaga, MP et al.
Int J Mol Sci , DOI://10.3390/ijms232113108 (2022)

thumbnail image from paper Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters
Liu, S; Stauft, CB; Selvaraj, P et al.
Nat Commun , DOI://10.1038/s41467-022-34571-4 (2022)

thumbnail image from paper Higher order interactions of Bcr-Abl can broaden chronic myeloid leukemia (CML) drug repertoire
Liu, Y; Zhang, M; Jang, H; Nussinov, R; ,
Protein Sci , DOI://10.1002/pro.4504 (2022)

thumbnail image from paper Vaccination History, Body Mass Index, Age, and Baseline Gene Expression Predict Influenza Vaccination Outcomes
Forst, CV; Chung, M; Hockman, M et al.
Viruses , DOI://10.3390/v14112446 (2022)