The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

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Biowulf Utilization
Monday, March 4th, 2024
utilization graph
Last 24 hrs
60,024 jobs submitted
34,459 jobs completed
2,403,858 CPU hrs used
23 NIH Institutes
245 Principal Investigators
482 users

Announcements

COVID-19 Research Support

The enhanced priority for Covid-related projects on Biowulf was retired in June 2023. Since 2020, this priority has resulted in

89.1+ Million CPU hours used
2.2+ Million Covid research jobs run
79 Peer-Reviewed papers
26 Preprint papers

[More about Covid projects on Biowulf]

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase
Collette, AM; Hassan, SA; Schmidt, SI et al.
Sci Adv , DOI://10.1126/sciadv.adj8829 (2024)


thumbnail image from paper The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity
Folco, HD; Xiao, H; Wheeler, D et al.
Nucleic Acids Res , DOI://10.1093/nar/gkad1182 (2024)


ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer
Vilasi, SM; Nguyen, J; Wang, CJ et al.
Cancers (Basel) , DOI://10.3390/cancers16040788 (2024)


Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Ou, AH; Rosenthal, SB; Adli, M et al.
Transl Psychiatry , DOI://10.1038/s41398-024-02811-4 (2024)


Comparative evolution of influenza A virus H1 and H3 head and stalk domains across host species
Trovão, NS; Khan, SM; Lemey, P et al.
mBio , DOI://10.1128/mbio.02649-23 (2024)


Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci
Bayram, E; Reho, P; Litvan, I et al.
NPJ Parkinsons Dis , DOI://10.1038/s41531-024-00649-7 (2024)


Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models
Hogan, CH; Owens, SM; Reynoso, GV et al.
mBio , DOI://10.1128/mbio.02998-23 (2024)


Association of cardiovascular disease management drugs with Lewy body dementia: a case-control study
Scholz, SW; Moroz, BE; Saez-Atienzar, S et al.
Brain Commun , DOI://10.1093/braincomms/fcad346 (2024)