The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational
Quick Links
System Status How To...
Application/DB updates User Guides
Policies Training
Contact Us

Biowulf Utilization
Saturday, December 9th, 2023
utilization graph
Last 24 hrs
55,195 jobs submitted
37,716 jobs completed
3,266,754 CPU hrs used
24 NIH Institutes
225 Principal Investigators
458 users

Announcements
(All)

COVID-19 Research Support

The enhanced priority for Covid-related projects on Biowulf was retired in June 2023. Since 2020, this priority has resulted in

89.1+ Million CPU hours used
2.2+ Million Covid research jobs run
79 Peer-Reviewed papers
26 Preprint papers

[More about Covid projects on Biowulf]

Recent Papers that used Biowulf & HPC Resources
(All 5662 papers)

thumbnail image from paper Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems
Nicastro, GG; Burroughs, AM; Iyer, LM; Aravind, L; ,
Nucleic Acids Res , DOI://10.1093/nar/gkad879 (2023)


thumbnail image from paper Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
Aggarwal, M; Striegel, DA; Hara, M; Periwal, V; ,
PLoS Comput Biol , DOI://10.1371/journal.pcbi.1011617 (2023)


thumbnail image from paper SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci
Thakur, BL; Kusi, NA; Mosavarpour, S et al.
Cells , DOI://10.3390/cells12222630 (2023)


thumbnail image from paper Discovery of a Novel Intron in US10/US11/US12 of HSV-1 Strain 17
Chang, W; Hao, M; Qiu, J et al.
Viruses , DOI://10.3390/v15112144 (2023)


thumbnail image from paper Effects of stopping criterion on the growth of trees in regression random forests
Arsham, A; Rosenberg, P; Little, M; ,
N Engl J Stat Data Sci , DOI://10.51387/22-nejsds5 (2023)


thumbnail image from paper Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
Xue, D; Narisu, N; Taylor, DL et al.
Cell Metab , DOI://10.1016/j.cmet.2023.09.013 (2023)


thumbnail image from paper Mapping the individual human cortex using multidimensional MRI and unsupervised learning
Kundu, S; Barsoum, S; Ariza, J et al.
Brain Commun , DOI://10.1093/braincomms/fcad258 (2023)


thumbnail image from paper A genome catalog of the early-life human skin microbiome
Shen, Z; Robert, L; Stolpman, M et al.
Genome Biol , DOI://10.1186/s13059-023-03090-w (2023)