The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Thursday, June 25th, 2026
utilization graph
Last 24 hrs
113,900 jobs submitted
96,482 jobs completed
2,251,034 CPU hrs used
23 NIH Institutes
346 Principal Investigators
798 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6889 papers)

thumbnail image from paper FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins
Min, J; Brooks, BR; Amin, M; ,
BMC Bioinformatics , DOI://10.1186/s12859-026-06448-6 (2026)


Unlocking Selenium Chemical Space via a Programmable Synthesis Platform Bearing Cannabinoid Receptor Recognition Motifs
Iyer, MR; Bhattacharjee, P; Dutta, S et al.
J Am Chem Soc , DOI://10.1021/jacs.5c16359 (2026)


Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making
Robins, PL; Gilbert, JR; Luber, B et al.
Hum Brain Mapp , DOI://10.1002/hbm.70529 (2026)


Escherichia coli pathobionts and Crohn's disease: varied genetic paths leading to similar phenotypes
Arroyo-Mendoza, M; Lorenzi, H; Phillips, GJ; Hinton, DM; ,
J Bacteriol , DOI://10.1128/jb.00016-26 (2026)


Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism
Lee, HK; Pyatkov, M; Gavrilova, O et al.
Endocrinology , DOI://10.1210/endocr/bqag057 (2026)


Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1
Kumar, R; May, G; Sen, ND et al.
Nucleic Acids Res , DOI://10.1093/nar/gkag427 (2026)


ASF1B promotes erythropoiesis by regulating the establishment and enrichment of H3.3 nucleosomes
Liu, J; Song, X; Zhou, L et al.
Nucleic Acids Res , DOI://10.1093/nar/gkag447 (2026)


Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF
Demiral, SB; Benveniste, H; Volkow, ND; ,
Neuroimage , DOI://10.1016/j.neuroimage.2026.121971 (2026)