The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, July 8th, 2025
utilization graph
Last 24 hrs
92,013 jobs submitted
59,849 jobs completed
2,618,124 CPU hrs used
24 NIH Institutes
301 Principal Investigators
630 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6457 papers)

Basal ganglia activation localized in MEG using a reward task
Sepe-Forrest, L; Carver, FW; Quentin, R et al.
Neuroimage Rep , DOI://10.1016/j.ynirp.2021.100034 (2021)


A Dataset of Medical Questions Paired with Automatically Generated Answers and Evidence-supported References
Gupta, D; Bartels, D; Demner-Fushman, D; ,
Sci Data , DOI://10.1038/s41597-025-05233-z (2025)


thumbnail image from paper EzSEA: an interactive web interface for enzyme sequence evolution analysis
Jiang, AK; Zhao, J; Jiang, X; ,
Bioinform Adv , DOI://10.1093/bioadv/vbaf118 (2025)


Material properties of biomolecular condensates emerge from nanoscale dynamics
Galvanetto, N; Ivanović, MT; Del Grosso, SA et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2424135122 (2025)


Tevenvirinae phages encode a family of LSm-like fold proteins
Kim, J; Tai, CH; Livingston, NK et al.
Comput Struct Biotechnol J , DOI://10.1016/j.csbj.2025.05.028 (2025)


GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians
Ojo, OO; Bandres-Ciga, S; Makarious, MB et al.
Mov Disord , DOI://10.1002/mds.29753 (2024)


Optimization of the PROTAC linker region of the proteasome substrate receptor hRpn13 rationalized by structural modeling with molecular dynamics
Lu, X; Sabbasani, VR; Hassan, B et al.
J Biol Chem , DOI://10.1016/j.jbc.2025.108520 (2025)


thumbnail image from paper SECONDGRAM: Self-conditioned diffusion with gradient manipulation for longitudinal MRI imputation
Theodorou, B; Dadu, A; Nalls, M et al.
Patterns (N Y) , DOI://10.1016/j.patter.2025.101212 (2025)