The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

89.0+ Million CPU hours used
2.2+ Million jobs run
67 Peer-Reviewed papers
27 Preprint papers

Sample projects (All projects):

  • Assessing newly generated and previously known compounds for activity against SARS-Cov-2 [NCI]
  • Modeling unreported SARS-Cov2 infection from observed cases, computational modeling of Covid-19 biological systems. [NIDDK]
  • Genome-wide association study of COVID-19 genetic variants vs. phenotypes in the UK BioBank [NHLBI]
  • Genome-wide association studies to identify common and rare germline genetic variants associated with susceptibility to severe or fatal COVID-19 disease [NCI_DCEG]
  • Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]
  • Simulations of infection spread in populations [NIDDK]
  • In silico screening of drug candidates [NCI]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Tuesday, May 30th, 2023
utilization graph
Last 24 hrs
205,537 jobs submitted
187,988 jobs completed
2,711,213 CPU hrs used
22 NIH Institutes
222 Principal Investigators
419 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning
Gorka, AX; Philips, RT; Torrisi, S et al.
Soc Cogn Affect Neurosci , DOI://10.1093/scan/nsad025 (2023)

thumbnail image from paper Inflammatory and interferon gene expression signatures in patients with mitochondrial disease
Warren, EB; Gordon-Lipkin, EM; Cheung, F et al.
J Transl Med , DOI://10.1186/s12967-023-04180-w (2023)

thumbnail image from paper Influenza A viruses in gulls in landfills and freshwater habitats in Minnesota, United States
Rasmussen, EA; Czaja, A; Cuthbert, FJ et al.
Front Genet , DOI://10.3389/fgene.2023.1172048 (2023)

thumbnail image from paper Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
Gochman, A; Tan, XF; Bae, C et al.
Elife , DOI://10.7554/eLife.86166 (2023)

thumbnail image from paper Constitutive and conditional PACAP deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of PACAP
Dana Bakalar, Oksana Gavrilova, Sunny Z. Jiang, Hai-ying Zhang, Snehashis Roy, Sarah K. Williams, Naili Liu, Stephen Wisser, Ted B. Usdin, Lee E. Eiden
Journal of Neuroendocrinology , 10.1111/jne.13286 (2023)

thumbnail image from paper AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults
Maxime Nachit , Yves Horsmans, Ronald M. Summers, Isabelle A. Leclercq, Perry J. Pickhardt
Radiology , doi://10.1148/radiol.222008 (2023)

Protocol for using single-cell sequencing to study the heterogeneity of NF1 nerve sheath tumors from clinical biospecimens
Zhang, X; Gopalan, V; Syed, N et al.
STAR Protoc , DOI://10.1016/j.xpro.2023.102297 (2023)

thumbnail image from paper Tracking the emergence of antigenic variants in influenza A virus epidemics in Brazil
Pillai, TK; Johnson, KE; Song, T et al.
Virus Evol , DOI://10.1093/ve/vead027 (2023)

thumbnail image from paper Country-level gender inequality is associated with structural differences in the brains of women and men
Zugman, A; Alliende, LM; Medel, V et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2218782120 (2023)

thumbnail image from paper Genome and Genetic Engineering of the House Cricket (Acheta domesticus): A Resource for Sustainable Agriculture
Dossey, AT; Oppert, B; Chu, FC et al.
Biomolecules , DOI://10.3390/biom13040589 (2023)