The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, June 30th, 2026
utilization graph
Last 24 hrs
99,261 jobs submitted
82,566 jobs completed
2,008,957 CPU hrs used
23 NIH Institutes
351 Principal Investigators
755 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6892 papers)

CATS-A tool to contextualize cancer hallmarks to specific cancer types
Sharmin, M; Olgun, G; Agrawal, P et al.
iScience , DOI://10.1016/j.isci.2026.116374 (2026)


Compression of functional gradients during early nonrapid eye movement sleep
Tomasi, D; Volkow, ND; ,
PNAS Nexus , DOI://10.1093/pnasnexus/pgag221 (2026)


Polycomb-mediated 3D-genome organization controls replication timing
Chetlangia, N; Thakur, BL; Redon, CE et al.
Sci Adv , DOI://10.1126/sciadv.adx7445 (2026)


thumbnail image from paper FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins
Min, J; Brooks, BR; Amin, M; ,
BMC Bioinformatics , DOI://10.1186/s12859-026-06448-6 (2026)


Unlocking Selenium Chemical Space via a Programmable Synthesis Platform Bearing Cannabinoid Receptor Recognition Motifs
Iyer, MR; Bhattacharjee, P; Dutta, S et al.
J Am Chem Soc , DOI://10.1021/jacs.5c16359 (2026)


Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making
Robins, PL; Gilbert, JR; Luber, B et al.
Hum Brain Mapp , DOI://10.1002/hbm.70529 (2026)


Escherichia coli pathobionts and Crohn's disease: varied genetic paths leading to similar phenotypes
Arroyo-Mendoza, M; Lorenzi, H; Phillips, GJ; Hinton, DM; ,
J Bacteriol , DOI://10.1128/jb.00016-26 (2026)


Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism
Lee, HK; Pyatkov, M; Gavrilova, O et al.
Endocrinology , DOI://10.1210/endocr/bqag057 (2026)