Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

36.5+ Million CPU hours used
966+ Thousand jobs run

Sample projects (All projects):

  • Text mining of COVID-related scientific literature in LitCovid and CORD-19 [NLM/NCBI]
  • Modeling, global surveillance, real-time genomic sequencing and phylodynamics of SARS-CoV-2 [FIC]
  • Studying Interferon-induced variability in ACE2 expression levels [NCI]
  • Assessing newly generated and previously known compounds for activity against SARS-Cov-2 [NCI]
  • Deep Learning models of chest Xray and CT images [CC]
  • Covid-19 transmission modeling and crossover trials [NIAID]
  • Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Friday, December 4th, 2020
utilization graph
Last 24 hrs
95,660 jobs submitted
70,933 jobs completed
3,185,137 CPU hrs used
22 NIH Institutes
231 Principal Investigators
432 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms
Zhou, BR; Feng, H; Kale, S et al.
Mol Cell , DOI://10.1016/j.molcel.2020.10.038 (2020)

The sialotranscriptome of the gopher-tortoise tick, Amblyomma tuberculatum
Karim, S; Kumar, D; Adamson, S; Ennen, JR; Qualls, CP; Ribeiro, JMC; ,
Ticks Tick Borne Dis , DOI://10.1016/j.ttbdis.2020.101560 (2020)

Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors
Vasta, LM; McMaster, ML; Harney, LA et al.
Cancer Genet , DOI://10.1016/j.cancergen.2020.10.002 (2020)

thumbnail image from paper Coarse-grained modelling of DNA plectoneme pinning in the presence of base-pair mismatches
Desai, PR; Brahmachari, S; Marko, JF; Das, S; Neuman, KC; ,
Nucleic Acids Res , DOI://10.1093/nar/gkaa836 (2020)

thumbnail image from paper Predicting the course of ADHD symptoms through the integration of childhood genomic, neural, and cognitive features
Sudre, G; Sharp, W; Kundzicz, P et al.
Mol Psychiatry , DOI://10.1038/s41380-020-00941-x (2020)

thumbnail image from paper Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
Sajid, A; Lusvarghi, S; Murakami, M et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2016270117 (2020)

thumbnail image from paper Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells
Sciumè, G; Mikami, Y; Jankovic, D et al.
Immunity , DOI://10.1016/j.immuni.2020.09.008 (2020)

thumbnail image from paper Anxiety Patients Rely On Bilateral DLPFC Activation During Verbal Working Memory
Balderston, NL; Flook, E; Hsiung, A et al.
Soc Cogn Affect Neurosci , DOI://10.1093/scan/nsaa146 (2020)

thumbnail image from paper Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes
Brown, DW; Lin, SH; Loh, PR; Chanock, SJ; Savage, SA; Machiela, MJ; ,
PLoS Genet , DOI://10.1371/journal.pgen.1009078 (2020)

thumbnail image from paper Characterizing transcriptional regulatory sequences in coronaviruses and their role in recombination
Yang, Y; Yan, W; Hall, AB; Jiang, X; ,
Mol Biol Evol , DOI://10.1093/molbev/msaa281 (2020)