High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for short jobs, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.



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Cluster Utilization
Tuesday, June 27th, 2017
utilization graph
Last 24 hrs
88,480 jobs submitted
73,301 jobs completed
1,938,008 CPU hrs used
20 NIH Institutes
139 Principal Investigators
218 users

Announcements
Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer
Lindsay M. Morton Joshua N. Sampson Gregory T. Armstrong et al.
J. Natl. Cancer. Inst. , DOI: https://doi.org/10.1093/jnci/djx058 (2017)

thumbnail image from paper Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome
Zhao, Z; Xie, L; Bourne, PE;
PLoS ONE , DOI://10.1371/journal.pone.0179936 (2017)

thumbnail image from paper The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells
Iwata, S; Mikami, Y; Sun, HW et al.
Immunity , DOI://10.1016/j.immuni.2017.05.005 (2017)

thumbnail image from paper Graphite-Templated Amyloid Nanostructures Formed by A Potential Pentapeptide Inhibitor for Alzheimer's disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations
Li, N; Jang, H; Yuan, M et al.
Langmuir , DOI://10.1021/acs.langmuir.7b00414 (2017)

thumbnail image from paper Monte Carlo simulations of randomized clinical trials in epilepsy
DM Goldenholz, J Tharayil, R Moss, E Myers, WH Theodore
Annals of Clinical and Translational Neurology , DOI: 10.1002/acn3.426 (2017)

thumbnail image from paper Heightened amygdala responsiveness in s-carriers of 5-HTTLPR genetic polymorphism reflects enhanced cortical rather than subcortical inputs: An MEG study
Luo, Q; Holroyd, T; Mitchell, D et al.
Hum Brain Mapp , DOI://10.1002/hbm.23616 (2017)

thumbnail image from paper Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly
Chereji, RV; Bharatula, V; Elfving, N et al.
Nucleic Acids Res. , DOI://10.1093/nar/gkx491 (2017)

High-fidelity PCR enzyme with DNA-binding domain facilitates de novo gene synthesis
Dolgova, AS; Stukolova, OA;
3 Biotech , DOI://10.1007/s13205-017-0745-2 (2017)