The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Thursday, September 10th, 2026
utilization graph
Last 24 hrs
102,939 jobs submitted
90,530 jobs completed
1,915,312 CPU hrs used
22 NIH Institutes
335 Principal Investigators
703 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6995 papers)

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors
Du, L; Wilson, BAP; Moore, WJ et al.
J Med Chem , DOI://10.1021/acs.jmedchem.5c00649 (2025)


Chromosome X-wide association study in multiple system atrophy identifies sex-differential risk loci
Ray, A; Chia, R; Rasheed, M et al.
Brain , DOI://10.1093/brain/awag062 (2026)


Go figure: transparency in neuroscience images preserves context and clarifies interpretation
Taylor, PA; Aggarwal, H; Bandettini, PA et al.
Nat Methods , DOI://10.1038/s41592-026-03206-7 (2026)


Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults
Chitrala, KN; Moody, DLB; Mode, NA et al.
Environ Epigenet , DOI://10.1093/eep/dvag030 (2026)


CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice
Nakano, Y; Driver, EC; Hu, N et al.
iScience , DOI://10.1016/j.isci.2026.117341 (2026)


Plasma cell-CD8+ T cell co-enrichment distinguishes immunotherapy-responsive hepatocellular carcinoma subtypes
Neupane, A; Budhu, A; Mehrabadi, FR et al.
eGastroenterology , DOI://10.1136/egastro-2026-100423 (2026)


Methylation profiling of normal tissue adjacent to breast tumors reveals two distinct groups with divergent tumor microenvironment features
Koka, H; Lee, PMY; Zhu, B et al.
NPJ Breast Cancer , DOI://10.1038/s41523-026-00944-x (2026)


The role of chloride ions in serotonin transport
Huang, J; Backer, A; Uchendu, S et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2605760123 (2026)