Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

9.2+ Million CPU hours used
233+ Thousand jobs run

Sample projects (All projects):

  • In silico screening of drug candidates [NCI]
  • Genetic Determinants of Susceptibility to Severe COVID-19 Infection [NIAID]
  • Metagenomics of Covid-19 family [NLM]
  • Covid-19 transmission modeling [NIAID]
  • Genome-wide association study of COVID-19 genetic variants vs. phenotypes in the UK BioBank [NHLBI]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Saturday, July 11th, 2020
utilization graph
Last 24 hrs
93,201 jobs submitted
76,816 jobs completed
3,264,918 CPU hrs used
25 NIH Institutes
194 Principal Investigators
367 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Soy protein nanofiber scaffolds for uniform maturation of hiPSC-derived retinal pigment epithelium
Phelan, MA; Kruczek, K; Wilson, JP et al.
Tissue Eng Part C Methods , DOI://10.1089/ten.TEC.2020.0072 (2020)

thumbnail image from paper Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury
Wilflingseder, J; Willi, M; Lee, HK et al.
Nat Commun , DOI://10.1038/s41467-020-17205-5 (2020)

thumbnail image from paper Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance
Schnappauf, O; Zhou, Q; Moura, NS et al.
J. Clin. Immunol. , DOI://10.1007/s10875-020-00817-3 (2020)

thumbnail image from paper Comparison of Oral Microbiota Collected Using Multiple Methods and Recommendations for New Epidemiologic Studies
Yano, Y; Hua, X; Wan, Y et al.
mSystems , DOI://10.1128/mSystems.00156-20 (2020)

thumbnail image from paper Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Bulut, H; Hattori, SI; Aoki-Ogata, H et al.
Sci Rep , DOI://10.1038/s41598-020-65993-z (2020)

thumbnail image from paper A New Molecular-Mechanics Model for Simulations of Hydrogen Fluoride in Chemistry and Biology
Orabi, EA; Faraldo-Gomez, JD;
J Chem Theory Comput , DOI://10.1021/acs.jctc.0c00247 (2020)

thumbnail image from paper Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery
Guardia, CM; Tan, XF; Lian, T et al.
Cell Rep , DOI://10.1016/j.celrep.2020.107837 (2020)

thumbnail image from paper Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Park, YH; Remmers, EF; Lee, W et al.
Nat. Immunol. , DOI://10.1038/s41590-020-0705-6 (2020)

thumbnail image from paper Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer
Lin, Y; Nakatochi, M; Hosono, Y et al.
Nat Commun , DOI://10.1038/s41467-020-16711-w (2020)

thumbnail image from paper The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Zhu, B; Poeta, ML; Costantini, M et al.
Nat Commun , DOI://10.1038/s41467-020-16546-5 (2020)