The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Tuesday, July 23rd, 2024
utilization graph
Last 24 hrs
58,891 jobs submitted
38,394 jobs completed
2,696,366 CPU hrs used
25 NIH Institutes
268 Principal Investigators
598 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Weakly-Supervised Detection of Bone Lesions in CT
Sheng, T; Mathai, TS; Shieh, A; Summers, RM; ,
Proc SPIE Int Soc Opt Eng , DOI://10.1117/12.3008823 (2024)

thumbnail image from paper Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
Wu, Z; Dazelle, K; Abdullaev, Z et al.
Acta Neuropathol Commun , DOI://10.1186/s40478-024-01781-4 (2024)

thumbnail image from paper Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors
Kundu, B; Dvorácskó, S; Basu, A et al.
Molecules , DOI://10.3390/molecules29133036 (2024)

thumbnail image from paper Endogenous retroviruses are dysregulated in ALS
Pasternack, N; Doucet-O'Hare, T; Johnson, K et al.
iScience , DOI://10.1016/j.isci.2024.110147 (2024)

thumbnail image from paper The contribution of silencer variants to human diseases
Huang, D; Ovcharenko, I; ,
Genome Biol , DOI://10.1186/s13059-024-03328-1 (2024)

thumbnail image from paper The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors
Robey, RW; Fitzsimmons, CM; Guiblet, WM et al.
Mol Cancer Ther , DOI://10.1158/1535-7163.MCT-23-0144 (2024)

thumbnail image from paper Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2
Nguyen, A; Zhao, H; Myagmarsuren, D et al.
Elife , DOI://10.7554/eLife.94836 (2024)

thumbnail image from paper Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes
Robinson, W; Stone, JK; Schischlik, F et al.
Sci Adv , DOI://10.1126/sciadv.adj7402 (2024)