Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Quick Links

Biowulf Utilization
Saturday, April 20th, 2019
utilization graph
Last 24 hrs
28,411 jobs submitted
17,588 jobs completed
2,654,278 CPU hrs used
20 NIH Institutes
154 Principal Investigators
243 users

Announcements
Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Automated segmentation and quantification of aortic calcification at abdominal CT: application of a deep learning-based algorithm to a longitudinal screening cohort
Graffy, PM; Liu, J; O'Connor, S; Summers, RM; Pickhardt, PJ;
Abdom Radiol (NY) , DOI://10.1007/s00261-019-02014-2 (2019)

thumbnail image from paper A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
Marabelli, C; Marrocco, B; Pilotto, S et al.
Cell Rep , DOI://10.1016/j.celrep.2019.03.061 (2019)

thumbnail image from paper Halogen bond interactions of novel HIV-1 protease inhibitors (PI)(GRL-001-15 and GRL-003-15) with the flap of protease are critical for their potent activity against wild-type and multi-PI-resistant HIV-1 variants
Hattori, SI; Hayashi, H; Bulut, H et al.
Antimicrob. Agents Chemother. , DOI://10.1128/AAC.02635-18 (2019)

thumbnail image from paper Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
Blauwendraat, C; Heilbron, K; Vallerga, CL et al.
Mov. Disord. , DOI://10.1002/mds.27659 (2019)

thumbnail image from paper Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit
Altman, MO; Angel, M; Košík, I et al.
MBio , DOI://10.1128/mBio.00204-19 (2019)

thumbnail image from paper Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases
Tekola-Ayele, F; Lee, A; Workalemahu, T; Sánchez-Pozos, K;
Hum. Genomics , DOI://10.1186/s40246-019-0202-x (2019)

thumbnail image from paper Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico
Nelson, MI; Souza, CK; Trovão, NS et al.
Emerging Infect. Dis. , DOI://10.3201/eid2504.180779 (2019)

thumbnail image from paper Single-cell chromatin immunocleavage sequencing (scChIC-seq) to profile histone modification
Ku, WL; Nakamura, K; Gao, W et al.
Nat. Methods , DOI://10.1038/s41592-019-0361-7 (2019)