Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

87.1+ Million CPU hours used
2.0+ Million jobs run

Sample projects (All projects):

  • Modeling, global surveillance, real-time genomic sequencing and phylodynamics of SARS-CoV-2 [FIC]
  • Genome-wide association study of COVID-19 genetic variants vs. phenotypes in the UK BioBank [NHLBI]
  • Genome-wide association studies to identify common and rare germline genetic variants associated with susceptibility to severe or fatal COVID-19 disease [NCI_DCEG]
  • Determining the incidence of age-related clonal hematopoiesis in mild vs. severe COVID-19 patient [NHLBI]
  • Genetic Determinants of Susceptibility to Severe COVID-19 Infection [NIAID]
  • MD simulation of SARS-CoV-2 spike protein [NIAID_VRC]
  • Stochastic modeling of COVID-19 pandemic infection patterns [NIA]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Thursday, August 18th, 2022
utilization graph
Last 24 hrs
72,065 jobs submitted
50,358 jobs completed
3,169,039 CPU hrs used
26 NIH Institutes
258 Principal Investigators
522 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Sex-specific transcriptome differences in a middle-aged frailty cohort
Pacheco, NL; Noren Hooten, N; Zhang, Y et al.
BMC Geriatr , DOI://10.1186/s12877-022-03326-7 (2022)

thumbnail image from paper Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Banday, AR; Stanifer, ML; Florez-Vargas, O et al.
Nat Genet , DOI://10.1038/s41588-022-01113-z (2022)

thumbnail image from paper Emergence of Irregular Activity in Networks of Strongly Coupled Conductance-Based Neurons
Sanzeni, A; Histed, MH; Brunel, N;
Phys Rev X , DOI://10.1103/physrevx.12.011044 (0)

thumbnail image from paper Cholesterol Binds the Amphipathic Helix of IFITM3 and Regulates Antiviral Activity
Rahman, K; Datta, SAK; Beaven, AH et al.
J Mol Biol , DOI://10.1016/j.jmb.2022.167759 (2022)

thumbnail image from paper Magnetoencephalographic correlates of mood and reward dynamics in human adolescents
Liuzzi, L; Chang, KK; Zheng, C et al.
Cereb Cortex , DOI://10.1093/cercor/bhab417 (2022)

thumbnail image from paper MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition
Hua, X; Song, L; Yu, G et al.
Genes (Basel) , DOI://10.3390/genes13071224 (2022)

thumbnail image from paper Role of Lysosomal Gene Variants in Modulating GBA-Associated Parkinson's Disease Risk
Straniero, L; Rimoldi, V; Monfrini, E et al.
Mov Disord , DOI://10.1002/mds.28987 (2022)

thumbnail image from paper Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer
Tang, LY; Spezia, M; Chen, T et al.
Cell Biosci , DOI://10.1186/s13578-022-00857-9 (2022)

thumbnail image from paper Identification of Daboia siamensis venome using integrated multi-omics data
Saethang, T; Somparn, P; Payungporn, S et al.
Sci Rep , DOI://10.1038/s41598-022-17300-1 (2022)

thumbnail image from paper Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases
Shao, L; Pelayo, A; Shi, R et al.
J Transl Med , DOI://10.1186/s12967-022-03531-3 (2022)