The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Monday, April 21st, 2025
utilization graph
Last 24 hrs
62,458 jobs submitted
37,719 jobs completed
3,281,975 CPU hrs used
23 NIH Institutes
199 Principal Investigators
360 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6380 papers)

Role of charges in a dynamic disordered complex between an IDP and a folded domain
Bugge, K; Sottini, A; Ivanović, MT et al.
Nat Commun , DOI://10.1038/s41467-025-58374-5 (2025)


thumbnail image from paper Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter
Wang, L; Cui, CY; Lee, CT et al.
Nat Commun , DOI://10.1038/s41467-025-58466-2 (2025)


Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function
Schulhof, N; Sukprasert, P; Ruppin, E et al.
Algorithms , DOI://10.3390/a18030140 (2025)


thumbnail image from paper Fast and accurate peak skin dose estimation method for interventional fluoroscopy patients
Han, H; Streitmatter, SW; Kitahara, CM; Lee, C; ,
Med Phys , DOI://10.1002/mp.17667 (2025)


Interspecies surfactants serve as public goods enabling surface motility in Pseudomonas aeruginosa
Warrell, DL; Zarrella, TM; Machalek, C; Khare, A; ,
J Bacteriol , DOI://10.1128/jb.00281-24 (2024)


Hot beverage intake and oesophageal cancer in the UK Biobank: prospective cohort study
Inoue-Choi, M; Ramirez, Y; O'Connell, C et al.
Br J Cancer , DOI://10.1038/s41416-025-02953-2 (2025)


Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development
Lee, HK; Jankowski, J; Liu, C; Hennighausen, L; ,
J Mammary Gland Biol Neoplasia , DOI://10.1007/s10911-025-09582-8 (2025)


Comparative phenotypic and genotypic antimicrobial susceptibility surveillance in Achromobacter spp. through whole genome sequencing
Ray, S; Flemming, LK; Scudder, CJ et al.
Microbiol Spectr , DOI://10.1128/spectrum.02527-24 (2025)