Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

88.6+ Million CPU hours used
2.2+ Million jobs run
64 Peer-Reviewed papers
27 Preprint papers

Sample projects (All projects):

  • Cryo-electron microscopy of virus proteins and complexes [NCI_CCR]
  • Deep Learning models of chest Xray and CT images [CC]
  • SARS-CoV-2 RNA structural analyses [NIAMS]
  • Simulations of infection spread in populations [NIDDK]
  • Investigation of pathogenic characteristics of COVID-19 by analysis of RNA-seq data from human patients [NIDDK]
  • Text mining of COVID-related scientific literature in LitCovid and CORD-19 [NLM/NCBI]
  • Studying maturation of the SARS Cov2 main protease [NIDDK]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Tuesday, February 7th, 2023
utilization graph
Last 24 hrs
64,877 jobs submitted
41,926 jobs completed
2,661,437 CPU hrs used
26 NIH Institutes
286 Principal Investigators
579 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein
Kuhn, CC; Basnet, N; Bodakuntla, S et al.
Nat Commun , DOI://10.1038/s41467-023-36279-5 (2023)

thumbnail image from paper Estimation of cell lineages in tumors from spatial transcriptomics data
Ru, B; Huang, J; Zhang, Y et al.
Nat Commun , DOI://10.1038/s41467-023-36062-6 (2023)

thumbnail image from paper A filarial parasite-encoded human IL-10 receptor antagonist reveals a novel strategy to modulate host responses
Ricciardi, A; Hassan, SA; Kamenyeva, O et al.
PNAS Nexus , DOI://10.1093/pnasnexus/pgac184 (2022)

thumbnail image from paper Inflated expectations: Rare-variant association analysis using public controls
Kim, J; Karyadi, DM; Hartley, SW et al.
PLoS One , DOI://10.1371/journal.pone.0280951 (2023)

thumbnail image from paper Expression and subcellular localization of USH1C/harmonin in human retina provides insights into pathomechanisms and therapy
Nagel-Wolfrum, K; Fadl, BR; Becker, MM et al.
Hum Mol Genet , DOI://10.1093/hmg/ddac211 (2023)

thumbnail image from paper Revisiting the sialome of the cat flea Ctenocephalides felis
Lu, S; Danchenko, M; Macaluso, KR; Ribeiro, JMC; ,
PLoS One , DOI://10.1371/journal.pone.0279070 (2023)

Implementing machine learning methods with complex survey data: Lessons learned on the impacts of accounting sampling weights in gradient boosting
MacNell, N; Feinstein, L; Wilkerson, J et al.
PLoS One , DOI://10.1371/journal.pone.0280387 (2023)

thumbnail image from paper GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas
Machiela, MJ; Huang, WY; Wong, W et al.
Sci Data , DOI://10.1038/s41597-022-01921-2 (2023)

thumbnail image from paper Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype
Yoshida, T; Latt, KZ; Rosenberg, AZ et al.
Kidney Int Rep , DOI://10.1016/j.ekir.2022.10.011 (2023)

thumbnail image from paper The repertoire of CSF antiviral antibodies in patients with neuroinflammatory diseases
Enose-Akahata, Y; Wang, L; Almsned, F et al.
Sci Adv , DOI://10.1126/sciadv.abq6978 (2023)