The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Saturday, December 9th, 2023
utilization graph
Last 24 hrs
55,195 jobs submitted
37,716 jobs completed
3,266,754 CPU hrs used
24 NIH Institutes
225 Principal Investigators
458 users


COVID-19 Research Support

The enhanced priority for Covid-related projects on Biowulf was retired in June 2023. Since 2020, this priority has resulted in

89.1+ Million CPU hours used
2.2+ Million Covid research jobs run
79 Peer-Reviewed papers
26 Preprint papers

[More about Covid projects on Biowulf]

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems
Nicastro, GG; Burroughs, AM; Iyer, LM; Aravind, L; ,
Nucleic Acids Res , DOI://10.1093/nar/gkad879 (2023)

thumbnail image from paper Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
Aggarwal, M; Striegel, DA; Hara, M; Periwal, V; ,
PLoS Comput Biol , DOI://10.1371/journal.pcbi.1011617 (2023)

thumbnail image from paper SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci
Thakur, BL; Kusi, NA; Mosavarpour, S et al.
Cells , DOI://10.3390/cells12222630 (2023)

thumbnail image from paper Discovery of a Novel Intron in US10/US11/US12 of HSV-1 Strain 17
Chang, W; Hao, M; Qiu, J et al.
Viruses , DOI://10.3390/v15112144 (2023)

thumbnail image from paper Effects of stopping criterion on the growth of trees in regression random forests
Arsham, A; Rosenberg, P; Little, M; ,
N Engl J Stat Data Sci , DOI://10.51387/22-nejsds5 (2023)

thumbnail image from paper Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
Xue, D; Narisu, N; Taylor, DL et al.
Cell Metab , DOI://10.1016/j.cmet.2023.09.013 (2023)

thumbnail image from paper Mapping the individual human cortex using multidimensional MRI and unsupervised learning
Kundu, S; Barsoum, S; Ariza, J et al.
Brain Commun , DOI://10.1093/braincomms/fcad258 (2023)

thumbnail image from paper A genome catalog of the early-life human skin microbiome
Shen, Z; Robert, L; Stolpman, M et al.
Genome Biol , DOI://10.1186/s13059-023-03090-w (2023)