High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 60,000+ processor Linux cluster; Helix, an interactive system for short jobs, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.



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Cluster Utilization
Sunday, March 26th, 2017
utilization graph
Last 24 hrs
41,400 jobs submitted
25,071 jobs completed
1,365,912 CPU hrs used
20 NIH Institutes
94 Principal Investigators
140 users

Announcements
Recent Papers that used Biowulf & HPC Resources

Predicting drug-drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge
Takeda, T; Hao, M; Cheng, T; Bryant, SH; Wang, Y;
J Cheminform , DOI://10.1186/s13321-017-0200-8 (2017)

thumbnail image from paper Identification of β-Catenin-Interacting Proteins in Nuclear Fractions of Native Rat Collecting Duct Cells
Hwang, JR; Chou, CL; Medvar, B; Knepper, MA; Jung, HJ;
Am. J. Physiol. Renal Physiol. , DOI://10.1152/ajprenal.00054.2017 (2017)

BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice
Zhou, L; Canagarajah, B; Zhao, Y et al.
Dev. Cell , DOI://10.1016/j.devcel.2017.02.007 (2017)

thumbnail image from paper Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits
Yao, C; Joehanes, R; Johnson, AD et al.
Am. J. Hum. Genet. , DOI://10.1016/j.ajhg.2017.02.003 (2017)

thumbnail image from paper Effect of Detergent Micelle Environment on P-glycoprotein (ABCB1)-Ligand Interactions
Shukla, S; Abel, B; Chufan, EE; Ambudkar, SV;
J. Biol. Chem. , DOI://10.1074/jbc.M116.771634 (2017)

thumbnail image from paper Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome
Bickhart, DM; Rosen, BD; Koren, S et al.
Nat. Genet. , DOI://10.1038/ng.3802 (2017)

thumbnail image from paper SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation
Kidder, BL; Hu, G; Cui, K; Zhao, K;
Epigenetics Chromatin , DOI://10.1186/s13072-017-0115-7 (2017)

thumbnail image from paper FMRI Clustering in AFNI: False Positive Rates Redux
Robert W. Cox, Gang Chen, Daniel R. Glen, Richard C. Reynolds, Paul A. Taylor
Brain Connectivity , DOI: 10.1089/brain.2016.047 (2017)