Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

59.2+ Million CPU hours used
1.3+ Million jobs run

Sample projects (All projects):

  • Studying Interferon-induced variability in ACE2 expression levels [NCI]
  • Investigation of pathogenic characteristics of COVID-19 by analysis of RNA-seq data from human patients [NIDDK]
  • Genetic Determinants of Susceptibility to Severe COVID-19 Infection [NIAID]
  • MD simulation of SARS-CoV-2 spike protein [NIAID_VRC]
  • Metagenomics of Covid-19 family [NLM]
  • Image processing and text mining of clinical data for the NIAID COVID Data Management Working Group [NIAID]
  • Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Tuesday, April 20th, 2021
utilization graph
Last 24 hrs
69,645 jobs submitted
48,286 jobs completed
3,150,378 CPU hrs used
22 NIH Institutes
255 Principal Investigators
491 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper The structure, function and evolution of a complete human chromosome 8
Logsdon, GA; Vollger, MR; Hsieh, P et al.
Nature , DOI://10.1038/s41586-021-03420-7 (2021)

thumbnail image from paper A comprehensive macaque fMRI pipeline and hierarchical atlas
Jung, B; Taylor, PA; Seidlitz, J et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117997 (2021)

thumbnail image from paper Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Zhang, P; Kwon, AL; Guzzo, C et al.
mBio , DOI://10.1128/mBio.00090-21 (2021)

thumbnail image from paper Beyond linearity in neuroimaging: Capturing nonlinear relationships with application to longitudinal studies
Chen, G; Nash, TA; Cole, KM et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117891 (2021)

thumbnail image from paper CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning
Conrad, R; Narayan, K;
Elife , DOI://10.7554/eLife.65894 (2021)

thumbnail image from paper Martini 3: a general purpose force field for coarse-grained molecular dynamics
Souza, PCT; Alessandri, R; Barnoud, J et al.
Nat Methods , DOI://10.1038/s41592-021-01098-3 (2021)

thumbnail image from paper SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Yan, B; Freiwald, T; Chauss, D et al.
Sci Immunol , DOI://10.1126/sciimmunol.abg0833 (2021)

thumbnail image from paper A transcription-centric model of SNP-age interaction
Wang, K; Basu, M; Malin, J; Hannenhalli, S; ,
PLoS Genet , DOI://10.1371/journal.pgen.1009427 (2021)

Conception by fertility treatment and offspring deoxyribonucleic acid methylation
Yeung, EH; Mendola, P; Sundaram, R et al.
Fertil Steril , DOI://10.1016/j.fertnstert.2021.03.011 (2021)

thumbnail image from paper Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
Singh, K; Chen, YC; Hassanzadeh, S et al.
Front Genet , DOI://10.3389/fgene.2021.599261 (2021)