The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Sunday, June 16th, 2024
utilization graph
Last 24 hrs
28,283 jobs submitted
21,855 jobs completed
2,065,286 CPU hrs used
22 NIH Institutes
162 Principal Investigators
305 users

Recent Papers that used Biowulf & HPC Resources

Differentiating neural sensitivity and bias during face-emotion processing in youth: a computational approach
Haller, SP; Stoddard, J; Cardenas, SI et al.
Soc Cogn Affect Neurosci , DOI://10.1093/scan/nsae034 (2024)

thumbnail image from paper The complete sequence and comparative analysis of ape sex chromosomes
Makova, KD; Pickett, BD; Harris, RS et al.
Nature , DOI://10.1038/s41586-024-07473-2 (2024)

thumbnail image from paper De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
Villamor-Payà, M; Sanchiz-Calvo, M; Smak, J et al.
iScience , DOI://10.1016/j.isci.2024.109984 (2024)

thumbnail image from paper Systematic Assessment of Deep Learning-Based Predictors of Fragmentation Intensity Profiles
Hamaneh, MB; Ogurtsov, AY; Obolensky, OI; Yu, YK; ,
J Proteome Res , DOI://10.1021/acs.jproteome.3c00857 (2024)

thumbnail image from paper DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains
Balachandra, V; Shrestha, RL; Hammond, CM et al.
EMBO J , DOI://10.1038/s44318-024-00093-6 (2024)

thumbnail image from paper Multiplexing the Identification of Microorganisms via Tandem Mass Tag Labeling Augmented by Interference Removal through a Novel Modification of the Expectation Maximization Algorithm
Alves, G; Ogurtsov, AY; Porterfield, H et al.
J Am Soc Mass Spectrom , DOI://10.1021/jasms.3c00445 (2024)

thumbnail image from paper Decoupling the correlation between cytotoxic and exhausted T lymphocyte states enhances melanoma immunotherapy response prediction
Wang, B; Wang, K; Wu, D et al.
iScience , DOI://10.1016/j.isci.2024.109926 (2024)

thumbnail image from paper Exploring the transcriptome of immature stages of Ornithodoros hermsi, the soft-tick vector of tick-borne relapsing fever
de Sousa-Paula, LC; Berger, M; Talyuli, OAC et al.
Sci Rep , DOI://10.1038/s41598-024-62732-6 (2024)