The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Thursday, October 1st, 2026
utilization graph
Last 24 hrs
144,402 jobs submitted
104,789 jobs completed
2,306,056 CPU hrs used
22 NIH Institutes
355 Principal Investigators
793 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 7010 papers)

A Novel Sulfatide Analog Recognized by Human iNKT Cells Enhances Polyfunctional Antigen-Specific CD8+ T Cell Responses
Hara, A; DiSapio, J; Coombs, M et al.
Eur J Immunol , DOI://10.1002/eji.70285 (2026)


Secreted filarial acetylcholine analogs modulate parasite reproduction and host physiology
Grote, A; Ficaro, L; Koussa, J et al.
Nat Commun , DOI://10.1038/s41467-026-77090-2 (2026)


A new AI assisted approach aligns data standards and accelerates interoperability in biomedical research
Long, RA; Ballard, S; Shah, S et al.
NPJ Digit Med , DOI://10.1038/s41746-026-02795-z (2026)


Cytotoxic Microspinosamides from the Marine Sponge Geodia microspinosa That Decrease Diffuse Pleural Mesothelioma Viability
Orfanoudaki, M; Wang, D; Du, L et al.
Mar Drugs , DOI://10.3390/md24090308 (2026)


The Global Parkinson's Disease Genetics (GP2) Genome Browser
Fang, ZH; Grant, RH; Vitale, D et al.
Mov Disord , DOI://10.1002/mds.70309 (2026)


Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders
Akula, N; Liu, S; Shah, S et al.
Neuropsychopharmacology , DOI://10.1038/s41386-026-02439-6 (2026)


Using Class and Domain Information to Address Domain Shift in Federated Learning
Chiou, CY; Huang, CR; Latour, LL et al.
IEEE Trans Neural Netw Learn Syst , DOI://10.1109/TNNLS.2026.3658584 (2026)


Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids
Ryu, S; Inman, J; Hong, H et al.
Commun Biol , DOI://10.1038/s42003-026-10180-5 (2026)