The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, June 17th, 2025
utilization graph
Last 24 hrs
169,353 jobs submitted
124,110 jobs completed
3,569,025 CPU hrs used
25 NIH Institutes
332 Principal Investigators
719 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6403 papers)

thumbnail image from paper SECONDGRAM: Self-conditioned diffusion with gradient manipulation for longitudinal MRI imputation
Theodorou, B; Dadu, A; Nalls, M et al.
Patterns (N Y) , DOI://10.1016/j.patter.2025.101212 (2025)


MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma
Liu, Z; Hong, JJ; Zhang, X et al.
Oncogenesis , DOI://10.1038/s41389-025-00557-2 (2025)


White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging
Gong, Z; Faulkner, ME; Akhonda, MABS et al.
Geroscience , DOI://10.1007/s11357-024-01392-w (2025)


Late-onset GM2 gangliosidosis: magnetic resonance imaging, diffusion tensor imaging, and correlational fiber tractography differentiate Tay-Sachs and Sandhoff diseases
Lewis, CJ; Chipman, SI; Johnston, JM et al.
J Neurol , DOI://10.1007/s00415-025-13091-3 (2025)


Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation
McGlinchey, RP; Ramos, S; Dimitriadis, EK et al.
Nat Commun , DOI://10.1038/s41467-025-58899-9 (2025)


thumbnail image from paper A Super Enhancer-Derived Enhancer RNA Acts Together with CTCF/Cohesin in Trans to Regulate Erythropoiesis
Xie, B; Dean, A; ,
Genes (Basel) , DOI://10.3390/genes16040389 (2025)


A Case for Automated Segmentation of MRI Data in Neurodegenerative Diseases: Type II GM1 Gangliosidosis
Lewis, CJ; Johnston, JM; D'Souza, P et al.
NeuroSci , DOI://10.3390/neurosci6020031 (2025)


Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation
Juarez-Contreras, I; Lopes, LJS; Holt, J et al.
Sci Adv , DOI://10.1126/sciadv.adu7190 (2025)