The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, June 23rd, 2026
utilization graph
Last 24 hrs
116,634 jobs submitted
91,051 jobs completed
2,262,839 CPU hrs used
24 NIH Institutes
352 Principal Investigators
783 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6701 papers)

Triarylselenonium triflates provide efficient access to no-carrier-added ortho-, meta-, and para-[18F]Fluoroarenes
Sypniewski, J; Lee, YS; Tran, P et al.
Chem Sci , DOI://10.1039/d6sc03006h (2026)


Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk
Genner, RM; Meredith, M; Daida, K et al.
NPJ Dement , DOI://10.1038/s44400-026-00094-8 (2026)


thumbnail image from paper Proton Transfer Mechanisms in the MmpL3 Transporter of Mycobacterium tuberculosis Studied by Computer Simulations
Lee, YS; Hassan, SA; Hurt, DE; ,
ACS Bio Med Chem Au , DOI://10.1021/acsbiomedchemau.5c00274 (2026)


Early skill learning is shaped by the offline emergence of expert synergies
Kistler, W; Fakhreddine, R; Rodriguez, GR et al.
Curr Biol , DOI://10.1016/j.cub.2026.05.032 (2026)


TriosCompass: a snakemake workflow for integrated detection of SNVs, indels, STRs, and structural de novo variants in parent-child trios
Zhu, W; Yeager, M; Dawson, ET et al.
Bioinformatics , DOI://10.1093/bioinformatics/btag319 (2026)


Causal relationship between epigenetic markers and type 2 diabetes in West African populations: a Mendelian randomisation analysis
Meeks, KAC; van der Linden, EL; Bentley, AR et al.
Diabetologia , DOI://10.1007/s00125-026-06716-3 (2026)


thumbnail image from paper ERK autoinhibition mechanism informs a drug combination strategy
Regev, C; Jang, H; Nussinov, R; ,
Protein Sci , DOI://10.1002/pro.70650 (2026)


Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis
Li, J; Yang, MT; Matsuda-Lennikov, M et al.
J Exp Med , DOI://10.1084/jem.20252527 (2026)