The NIH HPC group plans, manages and supports
high-performance computing systems specifically for use by the
intramural NIH community. These systems include
Biowulf,
a 105,000+ processor
Linux cluster;
Helix, an interactive system for
file transfer and management, and
Helixweb, which provides a number of web-based
scientific tools. We provide access to a wide range of computational
applications for genomics, molecular and structural biology, mathematical and
graphical analysis, image analysis, and other scientific fields.
The continued growth and support of NIH's Biowulf cluster is dependent upon
its demonstrable value to the NIH Intramural Research Program. If you publish
research that involved significant use of Biowulf, please cite the cluster.
Suggested citation text:
This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).
Quick Links
Biowulf Utilization
Tuesday, June 17th, 2025
Last 24 hrs
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169,353 jobs submitted
124,110 jobs completed
3,569,025 CPU hrs used
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25 NIH Institutes
332 Principal Investigators
719 users
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Announcements
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Recent Papers that used Biowulf & HPC Resources
SECONDGRAM: Self-conditioned diffusion with gradient manipulation for longitudinal MRI imputation Theodorou, B; Dadu, A; Nalls, M et al.
Patterns (N Y)
, DOI://10.1016/j.patter.2025.101212 (2025)
MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma Liu, Z; Hong, JJ; Zhang, X et al.
Oncogenesis
, DOI://10.1038/s41389-025-00557-2 (2025)
White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging Gong, Z; Faulkner, ME; Akhonda, MABS et al.
Geroscience
, DOI://10.1007/s11357-024-01392-w (2025)
Late-onset GM2 gangliosidosis: magnetic resonance imaging, diffusion tensor imaging, and correlational fiber tractography differentiate Tay-Sachs and Sandhoff diseases Lewis, CJ; Chipman, SI; Johnston, JM et al.
J Neurol
, DOI://10.1007/s00415-025-13091-3 (2025)
Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation McGlinchey, RP; Ramos, S; Dimitriadis, EK et al.
Nat Commun
, DOI://10.1038/s41467-025-58899-9 (2025)
A Super Enhancer-Derived Enhancer RNA Acts Together with CTCF/Cohesin in Trans to Regulate Erythropoiesis Xie, B; Dean, A; ,
Genes (Basel)
, DOI://10.3390/genes16040389 (2025)
A Case for Automated Segmentation of MRI Data in Neurodegenerative Diseases: Type II GM1 Gangliosidosis Lewis, CJ; Johnston, JM; D'Souza, P et al.
NeuroSci
, DOI://10.3390/neurosci6020031 (2025)
Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation Juarez-Contreras, I; Lopes, LJS; Holt, J et al.
Sci Adv
, DOI://10.1126/sciadv.adu7190 (2025)
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