Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Subtle predictive movements reveal actions regardless of social context
McMahon, EG; Zheng, CY; Pereira, F; Gonzalez, R; Ungerleider, LG; Vaziri-Pashkam, M;
J Vis , DOI://10.1167/19.7.16 (2019)

thumbnail image from paper Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1)
Abel, B; Tosh, DK; Durell, SR et al.
Mol. Pharmacol. , DOI://10.1124/mol.118.115295 (2019)

thumbnail image from paper Eye in a Disk: eyeIntegration Human Pan-Eye and Body Transcriptome Database Version 1.0
Swamy, V; McGaughey, D;
Invest. Ophthalmol. Vis. Sci. , DOI://10.1167/iovs.19-27106 (2019)

thumbnail image from paper Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations
Lona-Durazo, F; Hernandez-Pacheco, N; Fan, S et al.
BMC Genet. , DOI://10.1186/s12863-019-0765-5 (2019)

thumbnail image from paper Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis
Wei, BR; Halsey, CH; Hoover, SB et al.
Acad Pathol , DOI://10.1177/2374289519859841 (2018)

thumbnail image from paper Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis
Deniset, JF; Belke, D; Lee, WY et al.
Immunity , DOI://10.1016/j.immuni.2019.06.010 (2019)

thumbnail image from paper Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition
Amano, M; Bulut, H; Tamiya, S; Nakamura, T; Koh, Y; Mitsuya, H;
Sci Rep , DOI://10.1038/s41598-019-46082-2 (2019)

Novel Heterozygous Variants in KMT2D Associated with Holoprosencephaly
Tekendo-Ngongang, C; Kruszka, P; Martinez, AF; Muenke, M;
Clin. Genet. , DOI://10.1111/cge.13598 (2019)