High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Tuesday, October 23rd, 2018
utilization graph
Last 24 hrs
95,501 jobs submitted
66,994 jobs completed
3,237,614 CPU hrs used
22 NIH Institutes
208 Principal Investigators
373 users

Announcements
Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Molecular Recognition between Aβ-Specific Single-Domain Antibody and Aβ Misfolded Aggregates
Mingzhen Zhang, Jie Zheng, Ruth Nussinov and Buyong Ma
Antibodies , doi:10.3390/antib7030025 (2018)

thumbnail image from paper Comparison of the umbrella sampling and the double decoupling method in binding free energy predictions for SAMPL6 octa-acid host-guest challenges
Nishikawa, N; Han, K; Wu, X; Tofoleanu, F; Brooks, BR;
J. Comput. Aided Mol. Des. , DOI://10.1007/s10822-018-0166-2 (2018)

thumbnail image from paper Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast
Mehta, GD; Ball, DA; Eriksson, PR et al.
Mol. Cell , DOI://10.1016/j.molcel.2018.09.009 (2018)

Optimizing and evaluating biomarker combinations as trial-level general surrogates
Gabriel, EE; Sachs, MC; Daniels, MJ; Halloran, ME;
Stat Med , DOI://10.1002/sim.7996 (2018)

thumbnail image from paper Global genetic insight contributed by consanguineous Pakistani families segregating hearing loss
Richard, EM; Santos-Cortez, RL; Faridi, R et al.
Hum. Mutat. , DOI://10.1002/humu.23666 (2018)

thumbnail image from paper Interface-Based Structural Prediction of Novel Host-Pathogen Interactions
Guven-Maiorov, E; Tsai, CJ; Ma, B; Nussinov, R;
Methods Mol. Biol. , DOI://10.1007/978-1-4939-8736-8_18 (2019)

Accelerating QM/MM Free Energy Computations via Intramolecular Force Matching
Hudson, PS; Boresch, S; Rogers, DM; Woodcock, HL;
J Chem Theory Comput , DOI://10.1021/acs.jctc.8b00517 (2018)

thumbnail image from paper QuagmiR: A Cloud-based Application for IsomiR Big Data Analytics
Bofill-De Ros, X; Chen, K; Chen, S et al.
Bioinformatics , DOI://10.1093/bioinformatics/bty843 (2018)