Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

50.9+ Million CPU hours used
1.2+ Million jobs run

Sample projects (All projects):

  • Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]
  • Modeling, global surveillance, real-time genomic sequencing and phylodynamics of SARS-CoV-2 [FIC]
  • Covid-19 transmission modeling and crossover trials [NIAID]
  • Investigating the transcriptional regulators of hyper-inflammatory responses to SARs-CoV2 infection [NIDDK]
  • Genome-wide association studies to identify common and rare germline genetic variants associated with susceptibility to severe or fatal COVID-19 disease [NCI_DCEG]
  • Studying maturation of the SARS Cov2 main protease [NIDDK]
  • MD simulation of SARS-CoV-2 spike protein [NIAID_VRC]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Thursday, February 25th, 2021
utilization graph
Last 24 hrs
79,639 jobs submitted
55,622 jobs completed
3,738,711 CPU hrs used
23 NIH Institutes
257 Principal Investigators
500 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
Lee, HK; Knabl, L; Pipperger, L et al.
Sci Rep , DOI://10.1038/s41598-021-83110-6 (2021)

thumbnail image from paper Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids
Kruczek, K; Qu, Z; Gentry, J et al.
Stem Cell Reports , DOI://10.1016/j.stemcr.2020.12.018 (2021)

thumbnail image from paper Total Ortholog Median Matrix as an alternative unsupervised approach for phylogenomics based on evolutionary distance between protein coding genes
Maruyama, SR; Rogerio, LA; Freitas, PD; Teixeira, MMG; Ribeiro, JMC; ,
Sci Rep , DOI://10.1038/s41598-021-81926-w (2021)

thumbnail image from paper Dynamic sex chromosome expression in Drosophila male germ cells
Mahadevaraju, S; Fear, JM; Akeju, M et al.
Nat Commun , DOI://10.1038/s41467-021-20897-y (2021)

thumbnail image from paper Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang, Q; Bastard, P; Liu, Z et al.
Science , DOI://10.1126/science.abd4570 (2020)

thumbnail image from paper Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification
Zhang, X; van Rooij, JGJ; Wakabayashi, Y et al.
BMC Med Genomics , DOI://10.1186/s12920-020-00838-2 (2021)

thumbnail image from paper Assessment of assumptions underlying models of prokaryotic pangenome evolution
Sela, I; Wolf, YI; Koonin, EV; ,
BMC Biol , DOI://10.1186/s12915-021-00960-2 (2021)

thumbnail image from paper Scale-Free Dynamics in Animal Groups and Brain Networks
Ribeiro, TL; Chialvo, DR; Plenz, D; ,
Front Syst Neurosci , DOI://10.3389/fnsys.2020.591210 (2020)

thumbnail image from paper The genomic structure of a human chromosome 22 nucleolar organizer region determined by TAR cloning
Kim, JH; Noskov, VN; Ogurtsov, AY et al.
Sci Rep , DOI://10.1038/s41598-021-82565-x (2021)

thumbnail image from paper Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation
Beck, DB; Basar, MA; Asmar, AJ et al.
Sci Adv , DOI://10.1126/sciadv.abe2116 (2021)