The NIH HPC group plans, manages and supports
high-performance computing systems specifically for use by the
intramural NIH community. These systems include
Biowulf,
a 105,000+ processor
Linux cluster;
Helix, an interactive system for
file transfer and management, and
Helixweb, which provides a number of web-based
scientific tools. We provide access to a wide range of computational
applications for genomics, molecular and structural biology, mathematical and
graphical analysis, image analysis, and other scientific fields.
The continued growth and support of NIH's Biowulf cluster is dependent upon
its demonstrable value to the NIH Intramural Research Program. If you publish
research that involved significant use of Biowulf, please cite the cluster.
Suggested citation text:
This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).
Quick Links
Biowulf Utilization
Monday, April 21st, 2025
Last 24 hrs
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62,458 jobs submitted
37,719 jobs completed
3,281,975 CPU hrs used
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23 NIH Institutes
199 Principal Investigators
360 users
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Announcements
- 16 Apr 2025 : REMINDER: Virtual Walk-In Consult with HPC staff today (Wed 16 Apr)
- 14 Apr 2025 : Virtual Walk-In Consult for Biowulf Users (Wed 16 Apr)
- 9 Apr 2025 : TODAY, 11AM: 2025 Biowulf Seminar Series: Nadya I. Tarasova, PhD, Game-changers in computational drug discovery, Bldg 35A Rm 640
- 7 Apr 2025 : 2025 Biowulf Seminar Series: Nadya I. Tarasova, PhD, Game-changers in computational drug discovery, April 9, 11a, 35A/610
- 4 Apr 2025 : 2025 Biowulf Seminar Series: Nadya I. Tarasova, PhD, Game-changers in computational drug discovery, April 9, 11a, 35A/610
- 1 Apr 2025 : Reboots of Helix/Biowulf
- 12 Mar 2025 : REMINDER: Virtual Walk-In Consult with HPC staff today (Wed 12 Mar)
- 12 Mar 2025 : REMINDER: Virtual Walk-In Consult with HPC staff today (Wed 12 Mar)
- 10 Mar 2025 : Virtual Walk-In Consult for Biowulf Users (Wed 12 Mar)
- 24 Feb 2025 : Reboots of Helix/Biowulf
- 12 Feb 2025 : REMINDER: Virtual Walk-In Consult with HPC staff today (Wed 12 Feb)
- 11 Feb 2025 : Upcoming NIH HPC class "Deep Learning by Example on Biowulf - Class #6"
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Recent Papers that used Biowulf & HPC Resources
Role of charges in a dynamic disordered complex between an IDP and a folded domain Bugge, K; Sottini, A; Ivanović, MT et al.
Nat Commun
, DOI://10.1038/s41467-025-58374-5 (2025)
Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter Wang, L; Cui, CY; Lee, CT et al.
Nat Commun
, DOI://10.1038/s41467-025-58466-2 (2025)
Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function Schulhof, N; Sukprasert, P; Ruppin, E et al.
Algorithms
, DOI://10.3390/a18030140 (2025)
Fast and accurate peak skin dose estimation method for interventional fluoroscopy patients Han, H; Streitmatter, SW; Kitahara, CM; Lee, C; ,
Med Phys
, DOI://10.1002/mp.17667 (2025)
Interspecies surfactants serve as public goods enabling surface motility in Pseudomonas aeruginosa Warrell, DL; Zarrella, TM; Machalek, C; Khare, A; ,
J Bacteriol
, DOI://10.1128/jb.00281-24 (2024)
Hot beverage intake and oesophageal cancer in the UK Biobank: prospective cohort study Inoue-Choi, M; Ramirez, Y; O'Connell, C et al.
Br J Cancer
, DOI://10.1038/s41416-025-02953-2 (2025)
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development Lee, HK; Jankowski, J; Liu, C; Hennighausen, L; ,
J Mammary Gland Biol Neoplasia
, DOI://10.1007/s10911-025-09582-8 (2025)
Comparative phenotypic and genotypic antimicrobial susceptibility surveillance in Achromobacter spp. through whole genome sequencing Ray, S; Flemming, LK; Scudder, CJ et al.
Microbiol Spectr
, DOI://10.1128/spectrum.02527-24 (2025)
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