The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

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Biowulf Utilization
Sunday, September 24th, 2023
utilization graph
Last 24 hrs
73,846 jobs submitted
38,278 jobs completed
2,777,072 CPU hrs used
18 NIH Institutes
183 Principal Investigators
328 users


COVID-19 Research Support

The enhanced priority for Covid-related projects on Biowulf was retired in June 2023. Since 2020, this priority has resulted in

89.1+ Million CPU hours used
2.2+ Million Covid research jobs run
78 Peer-Reviewed papers
26 Preprint papers

[More about Covid projects on Biowulf]

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa
Baker, FS; Wang, J; Florez-Vargas, O et al.
J Interferon Cytokine Res , DOI://10.1089/jir.2023.0014 (2023)

HLA in isolated REM sleep behavior disorder and Lewy body dementia
Yu, E; Krohn, L; Ruskey, JA et al.
Ann Clin Transl Neurol , DOI://10.1002/acn3.51841 (2023)

Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
West, EE; Merle, NS; Kamiński, MM et al.
Immunity , DOI://10.1016/j.immuni.2023.07.014 (2023)

Noninvasive biomarkers in heart transplant: 2020-2021 year in review
Qian, X; Shah, P; Agbor-Enoh, S; ,
Curr Opin Organ Transplant , DOI://10.1097/MOT.0000000000000945 (2022)

thumbnail image from paper Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system
Gao, Y; Wang, Y; Chauss, D et al.
Nat Immunol , DOI://10.1038/s41590-023-01553-7 (2023)

thumbnail image from paper Chromatin remodeling of prostaglandin signaling in smooth muscle enables mouse embryo passage through the female reproductive tract
Xin, Q; Yu, G; Feng, I; Dean, J; ,
Dev Cell , DOI://10.1016/j.devcel.2023.08.025 (2023)

thumbnail image from paper Comparative Evaluation of Current Biochemical-, Sequencing-, and Proteomic-Based Identification Methods for the Streptococcus bovis Group
Putnam, NE; Youn, JH; Wallace, MA et al.
J Clin Microbiol , DOI://10.1128/jcm.01712-22 (2023)

An Artificial Intelligence Approach for Tackling Conformational Energy Uncertainties in Chiroptical Spectroscopies
Marton, G; Koenis, MAJ; Liu, HB et al.
Angew Chem Int Ed Engl , DOI://10.1002/anie.202307053 (2023)