Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate
Ji, Y; Fioravanti, J; Zhu, W et al.
Nat Commun , DOI://10.1038/s41467-019-09882-8 (2019)

thumbnail image from paper Differential Brain Mechanisms of Selection and Maintenance of Information during Working Memory
Quentin, R; King, JR; Sallard, E et al.
J. Neurosci. , DOI://10.1523/JNEUROSCI.2764-18.2019 (2019)

thumbnail image from paper Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive
Raju, M; Hassan, SA; Kavarthapu, R; Anbazhagan, R; Dufau, ML;
Sci Rep , DOI://10.1038/s41598-019-42857-9 (2019)

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer
Leko, V; McDuffie, LA; Zheng, Z et al.
J. Immunol. , DOI://10.4049/jimmunol.1801022 (2019)

thumbnail image from paper Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa
Povoleri, GAM; Nova-Lamperti, E; Scottà, C et al.
Nat. Immunol. , DOI://10.1038/s41590-018-0230-z (2018)

thumbnail image from paper Evolution of All-Atom Protein Force Fields to Improve Local and Global Properties
Zerze, GH; Zheng, W; Best, RB; Mittal, J;
J Phys Chem Lett , DOI://10.1021/acs.jpclett.9b00850 (2019)

thumbnail image from paper The mechanism of PI3Kα activation at the atomic level
Zhang, M; Jang, H; Nussinov, R;
Chem Sci , DOI://10.1039/c8sc04498h (2019)

thumbnail image from paper Association Between Childhood Anhedonia and Alterations in Large-Scale Resting-State Networks and Task-Evoked Activation
Pornpattananangkul, N; Leibenluft, E; Pine, DS; Stringaris, A;
JAMA Psychiatry , DOI://10.1001/jamapsychiatry.2019.0020 (2019)