Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

61.5+ Million CPU hours used
1.4+ Million jobs run

Sample projects (All projects):

  • Text mining of COVID-related scientific literature in LitCovid and CORD-19 [NLM/NCBI]
  • Modeling unreported SARS-Cov2 infection from observed cases, computational modeling of Covid-19 biological systems. [NIDDK]
  • SARS-CoV-2 RNA structural analyses [NIAMS]
  • Assessing newly generated and previously known compounds for activity against SARS-Cov-2 [NCI]
  • Cryo-electron microscopy of virus proteins and complexes [NCI_CCR]
  • Surveillance sequencing of SARS-CoV-2 and tracking of emerging variants of concern, Microbiome analysis of respiratory samples from covid19 patients. [NIAID]
  • Atomic-level structure of the SARS-CoV-2 spike using cryo-electron microscopy [NIAID_VRC]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Friday, May 7th, 2021
utilization graph
Last 24 hrs
126,653 jobs submitted
100,905 jobs completed
3,097,149 CPU hrs used
23 NIH Institutes
233 Principal Investigators
467 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Social Heterogeneity Drives Complex Patterns of the COVID-19 Pandemic: Insights From a Novel Stochastic Heterogeneous Epidemic Model (SHEM)
Alexander V. Maltsev & Michael D. Stern*
Front. Phys. , doi://10.3389/fphy.2020.609224 (2021)

thumbnail image from paper FIB-SEM as a Volume Electron Microscopy Approach to Study Cellular Architectures in SARS-CoV-2 and Other Viral Infections: A Practical Primer for a Virologist
Baena, V; Conrad, R; Friday, P et al.
Viruses , doi://10.3390/v13040611 (2021)

thumbnail image from paper Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease
Hourigan, CS; Dillon, LW; Gui, G et al.
J Clin Oncol , DOI://10.1200/JCO.19.03011 (2020)

thumbnail image from paper Assessment of ANG variants in Parkinson's disease
Grenn, FP; Moore, A; Bandres-Ciga, S et al.
Neurobiol Aging , DOI://10.1016/j.neurobiolaging.2021.03.006 (2021)

thumbnail image from paper The structure, function and evolution of a complete human chromosome 8
Logsdon, GA; Vollger, MR; Hsieh, P et al.
Nature , DOI://10.1038/s41586-021-03420-7 (2021)

thumbnail image from paper A comprehensive macaque fMRI pipeline and hierarchical atlas
Jung, B; Taylor, PA; Seidlitz, J et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117997 (2021)

thumbnail image from paper Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Thomas, A; Takahashi, N; Rajapakse, VN et al.
Cancer Cell , DOI://10.1016/j.ccell.2021.02.014 (2021)

thumbnail image from paper Synthetic lethality-mediated precision oncology via the tumor transcriptome
Lee, JS; Nair, NU; Dinstag, G et al.
Cell , DOI://10.1016/j.cell.2021.03.030 (2021)

thumbnail image from paper Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Zhang, P; Kwon, AL; Guzzo, C et al.
mBio , DOI://10.1128/mBio.00090-21 (2021)

thumbnail image from paper Beyond linearity in neuroimaging: Capturing nonlinear relationships with application to longitudinal studies
Chen, G; Nash, TA; Cole, KM et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117891 (2021)