High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, an 20,000+ processor Linux cluster; Helix, an interactive system for short jobs, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Cluster Utilization
Tuesday, November 24th, 2015
utilization graph
Last 24 hrs
160,926 jobs submitted
138,362 jobs completed
540,147 CPU hrs used
19 NIH Institutes
110 Principal Investigators
172 users

Recent Papers that used Helix and Biowulf

thumbnail image from paper Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog
Sotiria Tavoulari, Eleonora Margheritis, Anu Nagarajan, David C. DeWitt, Yuan-Wei Zhang, Edwin Rosado, Silvia Ravera, Elizabeth Rhoades, Lucy R. Forrest and Gary Rudnick
J. Biol. Chem. , doi: 10.1074/jbc.M115.692012 (2015)

thumbnail image from paper The C5-substituted Tetrahydropyrano-tetrahydofuran-derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs Including Darunavir
Manabu Aoki, Hironori Hayashi, Ravikiran S. Yedidi, Cuthbert D. Martyr, Yuki Takamatsu, Hiromi Aoki-Ogata, Teruya Nakamura, Hirotomo Nakata, Debananda Das, Yuriko Yamagata, Arun K. Ghosh and Hiroaki Mitsuya
J. Virology , doi: 10.1128/JVI.01829-15 (2015)

thumbnail image from paper Clinical feasibility of using mean apparent propagator (MAP) MRI to characterize brain tissue microstructure
Alexandru V. Avram, Joelle E. Sarlls, Alan S. Barnett, Evren Özarslan, Cibu Thomas, M. Okan Irfanoglu, Elizabeth Hutchinson, Carlo Pierpaoli, Peter J. Basser
NeuroImage , doi:10.1016/j.neuroimage.2015.11.027 (2015)

thumbnail image from paper Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific
Satya P. Singh, John F. Foley, Hongwei H. Zhang, Darrell E. Hurt, Jennifer L. Richards, Craig S. Smith, Fang Liao, and Joshua M. Farber
Molecular Pharmacology , doi: 10.1124/mol.115.099960 (2015)

thumbnail image from paper The Structural Basis of Actin Organization by Vinculin and Metavinculin
Laura Y. Kim, Peter M. Thompson, Hyunna T. Lee, Mihir Pershad, Sharon L. Campbell, Gregory M. Alushin
J. Mol. Biol. , doi:10.1016/j.jmb.2015.09.031 (2015)

thumbnail image from paper Analysis of SLC16A11 variants in 12,811 American Indians: genotype-obesity interaction for type 2 diabetes and an association with RNASEK expression
Michael Traurig, Robert L. Hanson, Alejandra Marinelarena, Sayuko Kobes, Paolo Piaggi, Shelley Cole, Joanne E. Curran, John Blangero, Harald Göring, Satish Kumar, Robert G. Nelson, Barbara V. Howard, William C. Knowler, Leslie J. Baier and Clifton Bogardus
Diabetes , doi: 10.2337/db15-0571 (2015)

thumbnail image from paper Genome-wide estimate of the heritability of Multiple System Atrophy
M. Federoff, T.R. Price, A. Sailer, S. Scholz, D. Hernandez, A. Nicolas, A.B. Singleton, M. Nalls, H. Houlden
Parkinsonism and Related Disorders , doi:10.1016/j.parkreldis.2015.11.005 (2015)