Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 90,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

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Biowulf Utilization
Wednesday, January 29th, 2020
utilization graph
Last 24 hrs
81,514 jobs submitted
52,881 jobs completed
2,799,555 CPU hrs used
24 NIH Institutes
224 Principal Investigators
461 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis
Korrapati, S; Taukulis, I; Olszewski, R et al.
Front Mol Neurosci , DOI://10.3389/fnmol.2019.00316 (2019)

thumbnail image from paper A Transcriptome-Wide Association Study (TWAS) Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer
Zhong, J; Jermusyk, A; Wu, L et al.
J. Natl. Cancer Inst. , DOI://10.1093/jnci/djz246 (2020)

thumbnail image from paper Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells
Magen, A; Nie, J; Ciucci, T et al.
Cell Rep , DOI://10.1016/j.celrep.2019.10.131 (2019)

thumbnail image from paper Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal
Kaya KD, Chen HY, Brooks MJ et al
Mol Vis (2019)

thumbnail image from paper Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Lalaoui, N; Boyden, SE; Oda, H et al.
Nature , DOI://10.1038/s41586-019-1828-5 (2020)

thumbnail image from paper Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance
Takamatsu, Y; Aoki, M; Bulut, H et al.
Antimicrob. Agents Chemother. , DOI://10.1128/AAC.00372-19 (2019)

thumbnail image from paper Benchmarking the Performance of Time-Dependent Density Functional Theory Methods on Biochromophores
Shao, Y; Mei, Y; Sundholm, D; Kaila, VRI;
J Chem Theory Comput , DOI://10.1021/acs.jctc.9b00823 (2019)

thumbnail image from paper Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications
Amano, M; Salcedo-Gómez, PM; Yedidi, RS et al.
Antimicrob. Agents Chemother. , DOI://10.1128/AAC.00466-19 (2019)