NIH HPC Systems

The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status

All Services Operational

COVID-19 Research Support

59.2+ Million CPU hours used
1.3+ Million jobs run

Sample projects (All projects):

Studying Interferon-induced variability in ACE2 expression levels [NCI]
Investigation of pathogenic characteristics of COVID-19 by analysis of RNA-seq data from human patients [NIDDK]
Genetic Determinants of Susceptibility to Severe COVID-19 Infection [NIAID]
MD simulation of SARS-CoV-2 spike protein [NIAID_VRC]
Metagenomics of Covid-19 family [NLM]
Image processing and text mining of clinical data for the NIAID COVID Data Management Working Group [NIAID]
Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]

Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization

Tuesday, April 20th, 2021

Last 24 hrs
69,645 jobs submitted 48,286 jobs completed 3,150,378 CPU hrs used	22 NIH Institutes 255 Principal Investigators 491 users

Announcements

(All)

20 Apr 2021 : REMINDER: Zoom-In Consult with HPC staff tomorrow (Wed 21 Apr)
20 Apr 2021 : Upcoming NIH HPC class "Deep Learning by Example on Biowulf - Class #2"
15 Apr 2021 : Zoom-In Consult for Biowulf Users (Wed 21 Apr)
13 Apr 2021 : Online Bash Scripting Class
12 Apr 2021 : "Julia for Scientific Computing" Slides and video are now available
31 Mar 2021 : Upcoming NIH HPC class "Julia for Scientific Computing"
16 Mar 2021 : REMINDER: Zoom-In Consult with HPC staff tomorrow (Wed 17 Mar)

Recent Papers that used Biowulf & HPC Resources

(All publications)

The structure, function and evolution of a complete human chromosome 8
Logsdon, GA; Vollger, MR; Hsieh, P et al.
Nature , DOI://10.1038/s41586-021-03420-7 (2021)

A comprehensive macaque fMRI pipeline and hierarchical atlas
Jung, B; Taylor, PA; Seidlitz, J et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117997 (2021)

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
Zhang, P; Kwon, AL; Guzzo, C et al.
mBio , DOI://10.1128/mBio.00090-21 (2021)

Beyond linearity in neuroimaging: Capturing nonlinear relationships with application to longitudinal studies
Chen, G; Nash, TA; Cole, KM et al.
Neuroimage , DOI://10.1016/j.neuroimage.2021.117891 (2021)

CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning
Conrad, R; Narayan, K;
Elife , DOI://10.7554/eLife.65894 (2021)

Martini 3: a general purpose force field for coarse-grained molecular dynamics
Souza, PCT; Alessandri, R; Barnoud, J et al.
Nat Methods , DOI://10.1038/s41592-021-01098-3 (2021)

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Yan, B; Freiwald, T; Chauss, D et al.
Sci Immunol , DOI://10.1126/sciimmunol.abg0833 (2021)

A transcription-centric model of SNP-age interaction
Wang, K; Basu, M; Malin, J; Hannenhalli, S; ,
PLoS Genet , DOI://10.1371/journal.pgen.1009427 (2021)

Conception by fertility treatment and offspring deoxyribonucleic acid methylation
Yeung, EH; Mendola, P; Sundaram, R et al.
Fertil Steril , DOI://10.1016/j.fertnstert.2021.03.011 (2021)

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection
Singh, K; Chen, YC; Hassanzadeh, S et al.
Front Genet , DOI://10.3389/fgene.2021.599261 (2021)