The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Thursday, July 23rd, 2026
utilization graph
Last 24 hrs
119,149 jobs submitted
95,555 jobs completed
2,177,017 CPU hrs used
24 NIH Institutes
365 Principal Investigators
813 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6901 papers)

Robust but independent sex differences in human brain function, structure, and behavior
Liu, S; Mahony, BW; Whitman, ET et al.
Nat Commun , DOI://10.1038/s41467-026-73262-2 (2026)


SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children
Xu, Q; Shi, L; , et al.
Nat Commun , DOI://10.1038/s41467-026-72996-3 (2026)


Estimating the heritability of longitudinal rate-of-change: genetic insights into PSA velocity in prostate cancer-free individuals
Zhang, P; Wang, X; Shi, J; Albert, PS; ,
Biostatistics , DOI://10.1093/biostatistics/kxag015 (2026)


Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality
Magrinelli, F; Tesson, C; Angelova, PR et al.
Nat Commun , DOI://10.1038/s41467-026-71351-w (2026)


Artificial intelligence in clinical genetics: current practice and attitudes among the clinical genetics workforce
Berkstresser, AM; Ledgister Hanchard, SE; Iacaboni, D et al.
Genet Med , DOI://10.1016/j.gim.2026.102645 (2026)


ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma
Okada, R; Mendoza, A; Nousome, D et al.
J Immunother Cancer , DOI://10.1136/jitc-2025-013726 (2026)


KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models
Li, X; Ohler, ZW; Day, A et al.
Sci Transl Med , DOI://10.1126/scitranslmed.adw9462 (2026)


CATS-A tool to contextualize cancer hallmarks to specific cancer types
Sharmin, M; Olgun, G; Agrawal, P et al.
iScience , DOI://10.1016/j.isci.2026.116374 (2026)