Biowulf High Performance Computing at the NIH

The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

83.2+ Million CPU hours used
2.0+ Million jobs run

Sample projects (All projects):

  • Simulations of infection spread in populations [NIDDK]
  • Cryo-electron microscopy of virus proteins and complexes [NCI_CCR]
  • Metagenomics of Covid-19 family [NLM]
  • In silico screening of drug candidates [NCI]
  • Deep Learning models of chest Xray and CT images [CC]
  • Determining the incidence of age-related clonal hematopoiesis in mild vs. severe COVID-19 patient [NHLBI]
  • MD simulation of SARS-CoV-2 spike protein [NIAID_VRC]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Thursday, May 19th, 2022
utilization graph
Last 24 hrs
128,826 jobs submitted
100,004 jobs completed
3,082,282 CPU hrs used
24 NIH Institutes
261 Principal Investigators
541 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Drugsniffer: An Open Source Workflow for Virtually Screening Billions of Molecules for Binding Affinity to Protein Targets
Venkatraman, V; Colligan, TH; Lesica, GT et al.
Front Pharmacol , DOI://10.3389/fphar.2022.874746 (2022)

thumbnail image from paper A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers
Hanada, KI; Zhao, C; Gil-Hoyos, R et al.
Cancer Cell , DOI://10.1016/j.ccell.2022.03.012 (2022)

thumbnail image from paper The mechanism of activation of MEK1 by B-Raf and KSR1
Maloney, RC; Zhang, M; Liu, Y et al.
Cell Mol Life Sci , DOI://10.1007/s00018-022-04296-0 (2022)

thumbnail image from paper Placental multi-omics integration identifies candidate functional genes for birthweight
Tekola-Ayele, F; Zeng, X; Chatterjee, S et al.
Nat Commun , DOI://10.1038/s41467-022-30007-1 (2022)

thumbnail image from paper A semiparametric kernel independence test with application to mutational signatures
Lee, D; Zhu, B; ,
J Am Stat Assoc , DOI://10.1080/01621459.2020.1871357 (2021)

thumbnail image from paper A T cell resilience model associated with response to immunotherapy in multiple tumor types
Zhang, Y; Trang, V; Palmer, DC et al.
Nat Med , DOI://10.1038/s41591-022-01799-y (2022)

thumbnail image from paper Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by an epigenetic mechanism
Nakayama, H; Ohnuki, H; Nakahara, M et al.
Biochem Biophys Res Commun , DOI://10.1016/j.bbrc.2022.04.069 (2022)

thumbnail image from paper Neural Networks for Classification and Image Generation of Aging in Genetic Syndromes
Duong D; Hu P.; et al
Front Genet. , 10.3389/fgene.2022.864092 (2022)

thumbnail image from paper BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant
Knabl, L; Lee, HK; Wieser, M et al.
Commun Med (Lond) , DOI://10.1038/s43856-022-00083-x (2022)

thumbnail image from paper Evolutionary history and introduction of SARS-CoV-2 Alpha VOC/B.1.1.7 in Pakistan through international travelers
Nasir, A; Bukhari, AR; Trovão, NS et al.
Virus Evol , DOI://10.1093/ve/veac020 (2022)