The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Current Status    All Services Operational

COVID-19 Research Support

88.7+ Million CPU hours used
2.2+ Million jobs run
67 Peer-Reviewed papers
27 Preprint papers

Sample projects (All projects):

  • Stochastic modeling of COVID-19 pandemic infection patterns [NIA]
  • Genome-wide association study of COVID-19 genetic variants vs. phenotypes in the UK BioBank [NHLBI]
  • Studying maturation of the SARS Cov2 main protease [NIDDK]
  • SARS-CoV-2 RNA structural analyses [NIAMS]
  • (1) Identification of drugs that can be repurposed for COVID-19 (2) Using genetic interactions like synthetic lethality and genome scale metabolic modeling to identify new drug targets and combination therapy for COVID-19 [NCI]
  • Transcriptomics and network analysis of SARS-CoV-2 infection [NHLBI]
  • Genome-wide association studies to identify common and rare germline genetic variants associated with susceptibility to severe or fatal COVID-19 disease [NCI_DCEG]
Biowulf users with COVID-related projects should contact the HPC staff to get increased priority for their jobs.

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Biowulf Utilization
Thursday, March 30th, 2023
utilization graph
Last 24 hrs
88,904 jobs submitted
59,220 jobs completed
3,601,230 CPU hrs used
26 NIH Institutes
277 Principal Investigators
618 users

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells
Chibly, AM; Patel, VN; Aure, MH et al.
NPJ Regen Med , DOI://10.1038/s41536-023-00290-7 (2023)

thumbnail image from paper Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies
Zhan, J; Lin, D; Watson, N et al.
Cancer Res Commun , DOI://10.1158/2767-9764.CRC-22-0306 (2023)

thumbnail image from paper THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior
Hebart, MN; Contier, O; Teichmann, L et al.
Elife , DOI://10.7554/eLife.82580 (2023)

thumbnail image from paper The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
Wedekind, LE; Mahajan, A; Hsueh, WC et al.
Diabetologia , DOI://10.1007/s00125-023-05870-2 (2023)

thumbnail image from paper Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development
Fu, Y; Miyazaki, K; Chiba, Y et al.
J Biol Chem , DOI://10.1016/j.jbc.2023.104638 (2023)

thumbnail image from paper A dataset for medical instructional video classification and question answering
Gupta, D; Attal, K; Demner-Fushman, D; ,
Sci Data , DOI://10.1038/s41597-023-02036-y (2023)

thumbnail image from paper The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism
Bressan, E; Reed, X; Bansal, V et al.
Cell Genom , DOI://10.1016/j.xgen.2023.100261 (2023)

thumbnail image from paper Progressive neuronal plasticity in primate visual cortex during stimulus familiarization
Koyano, KW; Esch, EM; Hong, JJ et al.
Sci Adv , DOI://10.1126/sciadv.ade4648 (2023)

thumbnail image from paper A deeper insight into the sialome of male and female Culex quinquefasciatus mosquitoes
Lu, S; Martin-Martin, I; Ribeiro, JM; Calvo, E; ,
BMC Genomics , DOI://10.1186/s12864-023-09236-1 (2023)

A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism
Andersen, JF; Lei, H; Strayer, EC et al.
Blood , DOI://10.1182/blood.2022019359 (2023)