The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

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Biowulf Utilization
Sunday, September 24th, 2023
utilization graph
Last 24 hrs
73,846 jobs submitted
38,278 jobs completed
2,777,072 CPU hrs used
18 NIH Institutes
183 Principal Investigators
328 users

Announcements
(All)

COVID-19 Research Support

The enhanced priority for Covid-related projects on Biowulf was retired in June 2023. Since 2020, this priority has resulted in

89.1+ Million CPU hours used
2.2+ Million Covid research jobs run
78 Peer-Reviewed papers
26 Preprint papers

[More about Covid projects on Biowulf]

Recent Papers that used Biowulf & HPC Resources
(All 5627 papers)

thumbnail image from paper IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa
Baker, FS; Wang, J; Florez-Vargas, O et al.
J Interferon Cytokine Res , DOI://10.1089/jir.2023.0014 (2023)


HLA in isolated REM sleep behavior disorder and Lewy body dementia
Yu, E; Krohn, L; Ruskey, JA et al.
Ann Clin Transl Neurol , DOI://10.1002/acn3.51841 (2023)


Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
West, EE; Merle, NS; Kamiński, MM et al.
Immunity , DOI://10.1016/j.immuni.2023.07.014 (2023)


Noninvasive biomarkers in heart transplant: 2020-2021 year in review
Qian, X; Shah, P; Agbor-Enoh, S; ,
Curr Opin Organ Transplant , DOI://10.1097/MOT.0000000000000945 (2022)


thumbnail image from paper Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system
Gao, Y; Wang, Y; Chauss, D et al.
Nat Immunol , DOI://10.1038/s41590-023-01553-7 (2023)


thumbnail image from paper Chromatin remodeling of prostaglandin signaling in smooth muscle enables mouse embryo passage through the female reproductive tract
Xin, Q; Yu, G; Feng, I; Dean, J; ,
Dev Cell , DOI://10.1016/j.devcel.2023.08.025 (2023)


thumbnail image from paper Comparative Evaluation of Current Biochemical-, Sequencing-, and Proteomic-Based Identification Methods for the Streptococcus bovis Group
Putnam, NE; Youn, JH; Wallace, MA et al.
J Clin Microbiol , DOI://10.1128/jcm.01712-22 (2023)


An Artificial Intelligence Approach for Tackling Conformational Energy Uncertainties in Chiroptical Spectroscopies
Marton, G; Koenis, MAJ; Liu, HB et al.
Angew Chem Int Ed Engl , DOI://10.1002/anie.202307053 (2023)