The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Wednesday, November 20th, 2024
utilization graph
Last 24 hrs
141,688 jobs submitted
110,613 jobs completed
3,658,992 CPU hrs used
25 NIH Institutes
337 Principal Investigators
747 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6243 papers)

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility
Choi, H; Zhou, L; Zhao, Y; Dean, J; ,
Nucleic Acids Res , DOI://10.1093/nar/gkae712 (2024)


thumbnail image from paper Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Alam, P; Hoyt, F; Artikis, E et al.
Acta Neuropathol , DOI://10.1007/s00401-024-02813-y (2024)


thumbnail image from paper The Bor1 elevator transport cycle is subject to autoinhibition and activation
Jiang, Y; Jiang, J; ,
Nat Commun , DOI://10.1038/s41467-024-53411-1 (2024)


thumbnail image from paper MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Chung, HJ; Rajan, S; Wu, Z et al.
Acta Neuropathol , DOI://10.1007/s00401-024-02803-0 (2024)


thumbnail image from paper Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity
Updegrove, TB; Delerue, T; Anantharaman, V et al.
Sci Adv , DOI://10.1126/sciadv.adq0791 (2024)


The Myc-associated zinc finger protein epigenetically controls expression of interferon-γ-stimulated genes by recruiting STAT1 to chromatin
Xiao, T; Li, X; Felsenfeld, G; ,
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2320938121 (2024)


Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity
Xu, M; Hong, JJ; Zhang, X et al.
EMBO J , DOI://10.1038/s44318-024-00206-1 (2024)


A machine learning model reveals expansive downregulation of ligand-receptor interactions that enhance lymphocyte infiltration in melanoma with developed resistance to immune checkpoint blockade
Sahni, S; Wang, B; Wu, D et al.
Nat Commun , DOI://10.1038/s41467-024-52555-4 (2024)