The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Monday, January 13th, 2025
utilization graph
Last 24 hrs
73,303 jobs submitted
56,571 jobs completed
2,893,336 CPU hrs used
22 NIH Institutes
243 Principal Investigators
510 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6288 papers)

The protein structurome of Orthornavirae and its dark matter
Mutz, P; Camargo, AP; Sahakyan, H et al.
mBio , DOI://10.1128/mbio.03200-24 (2024)


thumbnail image from paper Excess shed mesothelin disrupts pancreatic cancer cell clustering to impair peritoneal colonization
Ewa, T; Panchwagh, N; Tai, CH et al.
FASEB J , DOI://10.1096/fj.202400446R (2024)


SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac
Lee, HJ; Fenollar-Ferrer, C; Isgrig, K et al.
Sci Adv , DOI://10.1126/sciadv.adm8663 (2024)


African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Álvarez Jerez, P; Wild Crea, P; Ramos, DM et al.
Nat Struct Mol Biol , DOI://10.1038/s41594-024-01423-2 (2024)


A genome-first approach to characterize DICER1 pathogenic variant prevalence, penetrance and cancer, thyroid, and other phenotypes in 2 population-scale cohorts
Kim, J; Haley, J; Hatton, JN et al.
Genet Med Open , DOI://10.1016/j.gimo.2024.101846 (2024)


Increased frequency of CHEK2 germline pathogenic variants among individuals with dermatofibrosarcoma protuberans
Sargen, MR; Kim, J; Haley, JS et al.
Genet Med Open , DOI://10.1016/j.gimo.2024.101895 (2024)


Doxorubicin resistance involves modulation of interferon signaling, transcriptional bursting, and gene co-expression patterns of U-ISGF3-related genes
Trzaskoma, P; Jung, S; Kanno, Y et al.
Neoplasia , DOI://10.1016/j.neo.2024.101071 (2024)


HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state
Lee, M; Lu, M; Zhang, B et al.
Comput Struct Biotechnol J , DOI://10.1016/j.csbj.2024.11.020 (2024)