The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

Current Status    All Services Operational
Quick Links
System Status How To...
Application/DB updates User Guides
Policies Training
Contact Us

Biowulf Utilization
Saturday, January 3rd, 2026
utilization graph
Last 24 hrs
70,065 jobs submitted
59,944 jobs completed
1,694,986 CPU hrs used
22 NIH Institutes
240 Principal Investigators
443 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6623 papers)

A CGG Repeat Expansion in CSNK1E Associated with Progressive Myoclonic Epilepsy with Incomplete Penetrance
Akçimen, F; Alvarez Jerez, P; Guliyeva, U et al.
Mov Disord , DOI://10.1002/mds.30326 (2025)


Excess CMS morbidity and FEMA declarations: Phenome Wide Association Study of Generalized Linear Model interactions between CMS diagnostic code utilization and FEMA Incident types, 1999-2020
Williams, N
Inform Med Unlocked , DOI://10.1016/j.imu.2025.101716 (2025)


Artificial intelligence-based models for quantification of intra-pancreatic fat deposition and their clinical relevance: a systematic review of imaging studies
Joshi, T; Virostko, J; Petrov, MS; ,
Eur Radiol , DOI://10.1007/s00330-025-11808-6 (2026)


thumbnail image from paper NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA
Amin, R; Ha, NH; Qiu, T et al.
Mol Cell , DOI://10.1016/j.molcel.2025.11.010 (2025)


Epigenetic dysregulation in aged muscle stem cells drives mesenchymal progenitor expansion via IL-6 and Spp1 signaling
Riparini, G; Mackenzie, M; Naz, F et al.
Nat Aging , DOI://10.1038/s43587-025-01002-0 (2025)


Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory study
Johnston, JN; Yuan, P; Kadriu, B et al.
Transl Psychiatry , DOI://10.1038/s41398-025-03724-6 (2025)


thumbnail image from paper Interlocking host and viral cis-regulatory networks drive Merkel cell carcinoma
Miao, L; Milewski, D; Coxon, A et al.
J Clin Invest , DOI://10.1172/JCI188924 (2025)


Examination of HLA-DRB1*15-linked candidate antigens in Still's disease with and without lung disease and features of drug hypersensitivity
Kobrin, DM; Brown, DG; Burbelo, PD et al.
J Rheumatol , DOI://10.3899/jrheum.2025-0522 (2025)