The METAL software is designed to facilitate meta-analysis of large datasets (such as several whole genome scans) in a convenient, rapid and memory efficient manner.

• https://github.com/statgen/METAL

• Module Name: metal (see the modules page for more information)
• Example files in /usr/local/apps/metal/examples/

Allocate an interactive session and run the program. Sample session:

[user@biowulf]$ sinteractive
salloc.exe: Pending job allocation 46116226
salloc.exe: job 46116226 queued and waiting for resources
salloc.exe: job 46116226 has been allocated resources
salloc.exe: Granted job allocation 46116226
salloc.exe: Waiting for resource configuration
salloc.exe: Nodes cn3144 are ready for job

[user@cn3144 ~]$ module load metal
[user@cn3144 ~]$ cd /data/$USER/metal/examples/GlucoseExample
[user@cn3144 ~]$ metal << EOT 
MARKER SNP
WEIGHT N
ALLELE EFFECT_ALLELE NON_EFFECT_ALLELE
FREQ EFFECT_ALLELE_FREQ
EFFECT BETA
STDERR SE
PVAL P_VAL
PROCESS DGI_three_regions.txt
MARKER SNP
     ALLELE EFFECT_ALLELE NON_EFFECT_ALLELE
      FREQ FREQ_EFFECT
      WEIGHT N
      EFFECT BETA
      STDERR SE
      PVAL PVALUE
PROCESS MAGIC_FUSION_Results.txt
MARKER SNP
      DEFAULT 4108
      ALLELE AL1 AL2
      FREQ FREQ1
      EFFECT EFFECT
      STDERR SE
     PVAL PVALUE
PROCESS magic_SARDINIA.tbl
ANALYZE
Press Ctrl-D to submit these commands. Two output files will be created.
[...etc...]

[user@cn3144 ~]$ exit
salloc.exe: Relinquishing job allocation 46116226
[user@biowulf ~]$